Yuvanc Ercan, Tuglu Devrim, Ozan Tunc, Kisa Ucler, Balci Mahi, Batislam Ertan, Yilmaz Erdal
Department of Urology, Kirikkale University School of Medicine, Kirikkale, Turkey.
Department of Urology, Firat University School of Medicine, Elazig, Turkey.
Arch Med Sci. 2019 Oct 4;17(3):812-817. doi: 10.5114/aoms.2019.88320. eCollection 2021.
Obstruction of the ureter may occur due to congenital, iatrogenic or other reasons. This can cause hydronephrosis in the early stage and can lead to cellular inflammation, necrosis and atrophy in the kidney tissue. The aim of this paper is to evaluate the protective effect of pheniramine maleate (PM) and zofenopril on renal damage caused by hydronephrosis due to unilateral partial ureter obstruction.
Twenty-four female Sprague Dawley rats were divided into 4 groups. Group 1: sham group, group 2: partial unilateral ureteral obstruction (PUUO) group, group 3: PUUO + PM group, group 4: PUUO + zofenopril group. Paraoxonase (PON), total antioxidant status (TAS) and total oxidant status (TOS) of tissue and blood samples were measured and calculated. Tissue samples were evaluated histopathologically.
An increase in tissue TAS and a decrease in tissue TOS and OSI levels were detected in groups 3 and 4 compared to group 2 (both: < 0.01). Tissue PON levels showed an increase in groups 3 and 4 compared to groups 1 and 2 (both: < 0.01). Histopathological evaluation showed a decrease in interstitial inflammation and congestion in groups 3 and 4 compared to the control group ( < 0.001). The decrease was observed to be more significant in group 4 compared to group 3 ( < 0.01).
In our experimental study, we observed that PM and zofenopril reduce the oxidation and tissue damage caused by unilateral partial obstruction.
输尿管梗阻可能由于先天性、医源性或其他原因而发生。这在早期可导致肾积水，并可致使肾组织发生细胞炎症、坏死和萎缩。本文旨在评估马来酸氯苯那敏（PM）和佐芬普利对单侧部分输尿管梗阻所致肾积水引起的肾损伤的保护作用。
将24只雌性Sprague Dawley大鼠分为4组。第1组：假手术组，第2组：单侧部分输尿管梗阻（PUUO）组，第3组：PUUO + PM组，第4组：PUUO + 佐芬普利组。测量并计算组织和血液样本中的对氧磷酶（PON）、总抗氧化状态（TAS）和总氧化状态（TOS）。对组织样本进行组织病理学评估。
与第2组相比，第3组和第4组的组织TAS升高，组织TOS和氧化应激指数（OSI）水平降低（均为：<0.01）。与第1组和第2组相比，第3组和第4组的组织PON水平升高（均为：<0.01）。组织病理学评估显示，与对照组相比，第3组和第4组的间质炎症和充血减少（<0.001）。观察到第4组的减少比第3组更显著（<0.01）。
在我们的实验研究中，我们观察到PM和佐芬普利可减轻单侧部分梗阻引起的氧化和组织损伤。
