机器人 3D 生物打印技术修复大段骨缺损。
Robotic 3D bio-printing technology for repairing large segmental bone defects.
机构信息
State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, China.
School of Mechanical Engineering, Southeast University, China.
出版信息
J Adv Res. 2020 Nov 25;30:75-84. doi: 10.1016/j.jare.2020.11.011. eCollection 2021 May.
INTRODUCTION
The traditional clinical treatment of long segmental bone defects usually requires multiple operations and depends on donor availability. The 3D bio-printing technology constitutes a great potential therapeutic tool for such an injury. However, 3D bio-printing remains a major challenge.
OBJECTIVES
In this study, we report the repair of long segmental bone defects by 3D bio-printing using a robotic manipulator 3D printer in a swine model.
METHODS
We systematically optimized bio-ink gelation under physiological conditions to achieve desirable mechanical properties suitable for bone regeneration, and a D-H kinematic model was used to improve printing accuracy to 0.5 mm.
RESULTS
These technical improvements allowed the repair of long segmental defects generated on the right tibia of pigs using 3D bio-printing within 12 min. The 3D bio-printing group showed improved treatment effects after 3 months.
CONCLUSION
These findings indicated that robotic 3D bio-printing is promising for direct clinical application.
简介
传统的长节段骨缺损临床治疗通常需要多次手术，并且依赖供体的可用性。3D 生物打印技术为这种损伤构成了一种极具潜力的治疗工具。然而，3D 生物打印仍然是一个重大挑战。
目的
本研究报告了在猪模型中使用机器人操纵器 3D 打印机通过 3D 生物打印修复长节段骨缺损。
方法
我们系统地优化了生理条件下的生物墨水胶凝作用，以获得适合骨再生的理想机械性能，并使用 D-H 运动学模型将打印精度提高到 0.5mm。
结果
这些技术改进使得可以在 12 分钟内通过 3D 生物打印修复猪右侧胫骨上产生的长节段缺陷。3D 生物打印组在 3 个月后显示出改善的治疗效果。
结论
这些发现表明，机器人 3D 生物打印有望直接临床应用。
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