Liu Yue, Wang Jiaqi, Wu Changxin
Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, Institutes of Biomedical Sciences, Shanxi University, Taiyuan, China.
The Provincial Key Laboratories for Prevention and Treatment of Major Infectious Diseases Shanxi, Institutes of Biomedical Sciences, Shanxi University, Taiyuan, China.
Front Nutr. 2021 May 7;8:626254. doi: 10.3389/fnut.2021.626254. eCollection 2021.
Tuberculosis (TB), caused by attacking the lungs and other organs, is one of the most common infectious disease worldwide. According to the WHO's 2020 report, a quarter of the world's population were infected with , and ~1.4 million people died of TB. Therefore, TB is a significant public health concern, which requires cost-effective strategies for prevention and treatment. The microbiota has been considered as a "forgotten organ" and a complex dynamic ecosystem, which plays a significant role in many physiological processes, and its dysbiosis is closely associated with infectious disease. Recently, a few studies have indicated associations between TB and microbiota. This review summarizes studies concerning the alterations of the gut and respiratory microbiota in TB, and their relationship with host susceptibility to infection, indicating that microbiota signatures in different stages in TB progression could be considered as biomarkers for TB diagnosis and control. In addition, the potential role of probiotics and postbiotics in TB treatment was discussed.
结核病（TB）由[病原体名称未给出]侵袭肺部和其他器官引起，是全球最常见的传染病之一。根据世界卫生组织2020年的报告，世界四分之一的人口感染了[病原体名称未给出]，约140万人死于结核病。因此，结核病是一个重大的公共卫生问题，需要具有成本效益的预防和治疗策略。微生物群被认为是一个“被遗忘的器官”和一个复杂的动态生态系统，在许多生理过程中发挥着重要作用，其生态失调与传染病密切相关。最近，一些研究表明结核病与微生物群之间存在关联。本综述总结了关于结核病患者肠道和呼吸道微生物群改变及其与宿主对[病原体名称未给出]感染易感性关系的研究，表明结核病进展不同阶段的微生物群特征可被视为结核病诊断和控制的生物标志物。此外，还讨论了益生菌和后生元在结核病治疗中的潜在作用。
