Weller M, Heimann K, Wiedemann P
Department of Vitreoretinal Surgery, Universitätsaugenklinik, Köln, Federal Republic of Germany.
Graefes Arch Clin Exp Ophthalmol. 1988;226(3):252-4. doi: 10.1007/BF02181191.
Proliferative vitreoretinopathy (PVR), the major complication of rhegmatogenous retinal detachment and posterior segment ocular trauma, is a multistage disease process eventually resulting in traction retinal detachment. The migration of macrophages to a site of disrupted barriers between the vitreous, retina, and choroidea, respectively, is considered to be an important step in the early pathogenesis of PVR. In this study, we demonstrate the presence of numerous mononuclear phagocytes in a human PVR membrane by an APAAP (alkaline phosphatase-anti-alkaline phosphatase) immunostain using a monoclonal mouse anti-human macrophage antibody. This finding correlates with a highly positive fibronectin immunostain in the same specimen. Our results warrant further investigation of the involvement of mononuclear phagocytes in vitreoretinal proliferative disorders.
增殖性玻璃体视网膜病变（PVR）是孔源性视网膜脱离和眼后段外伤的主要并发症，是一个多阶段的疾病过程，最终导致牵拉性视网膜脱离。巨噬细胞分别迁移至玻璃体、视网膜和脉络膜之间屏障破坏的部位，被认为是PVR早期发病机制中的一个重要步骤。在本研究中，我们使用小鼠抗人巨噬细胞单克隆抗体，通过APAAP（碱性磷酸酶-抗碱性磷酸酶）免疫染色，证实在人类PVR膜中存在大量单核吞噬细胞。这一发现与同一标本中纤连蛋白免疫染色呈强阳性相关。我们的结果值得进一步研究单核吞噬细胞在玻璃体视网膜增殖性疾病中的作用。
