Council for Scientific and Industrial Research, Plant Genetic Resources Research Institute, Bunso P.O. Box 7, Ghana.
National Agrobiodiversity Center, National Institute of Agricultural Sciences, Rural Development Administration, Jeonju 54874, Republic of Korea.
Molecules. 2024 Oct 11;29(20):4826. doi: 10.3390/molecules29204826.
A cytokine storm is an intense inflammatory response characterized by the overproduction of proinflammatory cytokines, resulting in tissue damage, and organ dysfunction. Cytokines play a crucial role in various conditions, such as coronavirus disease, in which the immune system becomes overactive and releases excessive levels of cytokines, including interleukins, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). This anomalous response often leads to acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and multiple organ injury (MOI). Glucosinolates are plant secondary metabolites predominantly found in vegetables, but are also present in other species, such as Adens and L. When catalyzed by the enzyme myrosinase, glucosinolates produce valuable products, including sulforaphane, phenethyl isothiocyanate, 6-(methylsulfinyl) hexyl isothiocyanate, erucin, goitrin, and moringin. These hydrolyzed products regulate proinflammatory cytokine production by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B-cell (NF-κB) signaling pathway and stimulating the nuclear factor erythroid 2-related factor 2 () signaling pathway. This action can alleviate hyperinflammation in infected cells and modulate cytokine storms. In this review, we aimed to examine the potential role of glucosinolates in modulating cytokine storms and reducing inflammation in various conditions, such as coronavirus disease. Overall, we found that glucosinolates and their hydrolysis products can potentially attenuate cytokine production and the onset of cytokine storms in diseased cells. In summary, glucosinolates could be beneficial in regulating cytokine production and preventing complications related to cytokine storms.
细胞因子风暴是一种强烈的炎症反应，其特征是促炎细胞因子过度产生，导致组织损伤和器官功能障碍。细胞因子在各种情况下都起着至关重要的作用，如冠状病毒病，在这种情况下，免疫系统过度活跃并释放过多水平的细胞因子，包括白细胞介素、肿瘤坏死因子-α（TNF-α）和干扰素-γ（IFN-γ）。这种异常反应通常导致急性呼吸窘迫综合征（ARDS）、弥散性血管内凝血（DIC）和多器官损伤（MOI）。硫代葡萄糖苷是植物次生代谢物，主要存在于蔬菜中，但也存在于其他物种中，如 Adens 和 L. 当被酶 myrosinase 催化时，硫代葡萄糖苷会产生有价值的产物，包括萝卜硫素、苯乙基异硫氰酸酯、6-(甲基亚磺酰基)己基异硫氰酸酯、 erucin、goitrin 和 moringin。这些水解产物通过抑制核因子κ轻链增强子的活化 B 细胞（NF-κB）信号通路和刺激核因子红细胞 2 相关因子 2（Nrf2）信号通路来调节促炎细胞因子的产生。这种作用可以减轻感染细胞中的过度炎症并调节细胞因子风暴。在这篇综述中，我们旨在研究硫代葡萄糖苷在调节细胞因子风暴和减轻各种情况下的炎症，如冠状病毒病中的潜在作用。总的来说，我们发现硫代葡萄糖苷及其水解产物可能在减弱患病细胞中细胞因子的产生和细胞因子风暴的发生方面发挥作用。总之，硫代葡萄糖苷在调节细胞因子产生和预防与细胞因子风暴相关的并发症方面可能有益。
