Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
Fitoterapia. 2021 Jul;152:104939. doi: 10.1016/j.fitote.2021.104939. Epub 2021 May 23.
Phytochemical study on a non-medicinal part of a plant material for herbal medicine, the roots of Schisandra chinensis, was conducted to isolate five new triterpenes, schinensins A-D (1-4) and 3-O-methylchangnanic acid (5), together with 21 known compounds including 10 triterpenes, one sterol, two sesquiterpenes, seven lignans, and one flavonoid. The structures of new triterpenes (1-5) were assigned on the basis of spectroscopic analyses aided with TDDFT ECD calculations. Schinensin A (1) was a dinortriterpene possessing 28-norschiartane skeleton, while schinensins B-D (2-4) were assigned as 3,4:9,10-disecocycloartane, 3,4-secocycloartane, and cycloartane triterpenes, respectively. In an evaluation of antiproliferative activities against human cancer cell lines, some triterpenes exhibited significant activities against human breast carcinoma MCF-7 cells as compared to the other cell lines (A549, HeLa, and RPMI8226).
对草药五味子（Schisandra chinensis）的非药用部分的植物材料进行了植物化学研究，分离得到了五个新的三萜类化合物，五味子 A-D（1-4）和 3-O-甲基苍术酸（5），以及 21 种已知化合物，包括 10 种三萜类化合物、一种甾体、两种倍半萜类化合物、七种木脂素类化合物和一种黄酮类化合物。新三萜类化合物（1-5）的结构基于光谱分析，并辅以 TDDFT ECD 计算确定。五味子 A（1）是一种具有 28-降松香烷骨架的二降三萜类化合物，而五味子 B-D（2-4）则分别被归类为 3,4:9,10-双环阿替烷、3,4-开环阿替烷和环阿替烷三萜类化合物。在对人癌细胞系的抗增殖活性评价中，与其他细胞系（A549、HeLa 和 RPMI8226）相比，一些三萜类化合物对人乳腺癌 MCF-7 细胞表现出显著的活性。
