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疼痛与创伤:标准 A 创伤和压力性生活事件在疼痛与创伤后应激障碍关系中的作用。

Pain and Trauma: The Role of Criterion A Trauma and Stressful Life Events in the Pain and PTSD Relationship.

机构信息

VA Center of Excellence for Stress and Mental Health, San Diego, California; Research Service, VA San Diego Healthcare System, San Diego, California; Department of Psychiatry, University of California, San Diego, La Jolla, California.

VA Center of Excellence for Stress and Mental Health, San Diego, California; Research Service, VA San Diego Healthcare System, San Diego, California; Department of Psychiatry, University of California, San Diego, La Jolla, California.

出版信息

J Pain. 2021 Nov;22(11):1506-1517. doi: 10.1016/j.jpain.2021.04.015. Epub 2021 May 21.

Abstract

Chronic pain and post-traumatic stress disorder (PTSD) frequently co-occur, and research suggests that these 2 conditions exacerbate one another producing greater impact on normal functioning in combination than separately. The influence of traumatic experiences on both pain and PTSD has been shown, but the nature of this interplay remains unclear. Although Criterion A trauma is required for the diagnosis of PTSD, whether the association between PTSD and chronic pain is dependent on Criterion A is underexplored. In this observational cohort study, we examined the association between pain and PTSD-like symptoms in the context of Criterion A trauma in 5,791 men from the Vietnam Era Twin Registry. Correlations and mixed-effects regression models were used to evaluate the relationship between PTSD Checklist-Civilian Version symptoms and multiple indicators of pain from the Short Form McGill Pain Questionnaire across trauma history and chronic pain conditions. 53.21% of the participants experienced trauma consistent with DSM-IV Criterion A for PTSD. The associations between pain indicators and PTSD-like symptoms was stronger for individuals with a history of trauma but remained robust for individuals without trauma history. Small but significant interactions between past trauma and pain indicators and PTSD-like symptoms were observed. Findings were similar in a subsample of participants with history of chronic pain conditions. The relationship between PTSD-like symptoms and indicators of pain were largely independent of trauma consistent with Criterion A, highlighting the need to better understand and address stressful life events in chronic pain patients and pain concerns in individuals reporting trauma. PERSPECTIVE: This article demonstrates that the relationship between PTSD-like symptoms and indicators of pain is largely independent of trauma consistent with Criterion A. This finding highlights the need to better understand and address stressful life events in chronic pain patients and pain concerns in individuals reporting trauma.

摘要

慢性疼痛和创伤后应激障碍(PTSD)经常同时发生,研究表明这两种疾病相互加重,共同作用对正常功能的影响大于单独作用。创伤经历对疼痛和 PTSD 都有影响,但这种相互作用的性质尚不清楚。虽然 PTSD 的诊断需要符合 A 类创伤标准,但 PTSD 与慢性疼痛之间的关联是否依赖于 A 类创伤标准尚未得到充分探索。在这项观察性队列研究中,我们在越南时代双胞胎登记处的 5791 名男性中,研究了 A 类创伤背景下疼痛与 PTSD 样症状之间的关联。使用相关分析和混合效应回归模型,评估 PTSD 清单-平民版症状与短期 McGill 疼痛问卷多项疼痛指标之间的关系,跨越创伤史和慢性疼痛状况。53.21%的参与者经历了符合 DSM-IV PTSD A 类标准的创伤。在有创伤史的个体中,疼痛指标与 PTSD 样症状之间的关联更强,但在没有创伤史的个体中,这种关联仍然很强。过去创伤与疼痛指标和 PTSD 样症状之间存在小但显著的相互作用。在有慢性疼痛状况史的参与者亚组中,研究结果相似。PTSD 样症状与疼痛指标之间的关系在很大程度上独立于符合 A 类标准的创伤,这强调了需要更好地理解和处理慢性疼痛患者的生活应激事件以及报告创伤的个体的疼痛问题。观点:本文表明,PTSD 样症状与疼痛指标之间的关系在很大程度上独立于符合 A 类标准的创伤。这一发现强调了需要更好地理解和处理慢性疼痛患者的生活应激事件以及报告创伤的个体的疼痛问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd4c/8578317/42eb7a4538f7/nihms-1732595-f0001.jpg

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