Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, And College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, And College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Biomaterials. 2021 Jul;274:120893. doi: 10.1016/j.biomaterials.2021.120893. Epub 2021 May 19.
Cancer vaccines consisting of tumor-associated antigens (TAAs) can initiate a powerful antitumor immune response through antigen-presenting cells, such as dendritic cells (DCs) and macrophages, and have shown great potential in cancer prevention and therapy. However, poor anticancer efficacy and an uncertain immunization process have hitherto limited the application of cancer vaccines. Herein, a multifunctional nanovaccine comprising ovalbumin (OVA), MnO, and polydopamine (OMPN) was prepared by a facile one-pot method. OMPN displayed excellent anticancer efficacy against an orthotopic melanoma and could also prevent liver metastasis in a tumor re-challenge mice model. Additionally, the migration behavior of DCs in the inguinal lymph node after vaccination was tracked by MRI contrasted with OMPN, indicating successful DC activation and immune response. The superior anticancer efficacy, especially the high efficiency against tumor metastasis, and the capability of tracking the immunization process make OMPN a very promising multifunctional nanovaccine for cancer therapy.
癌症疫苗由肿瘤相关抗原（TAAs）组成，可以通过抗原呈递细胞（如树突状细胞和巨噬细胞）引发强大的抗肿瘤免疫反应，在癌症预防和治疗方面具有巨大潜力。然而，抗癌疗效不佳和免疫接种过程不确定，迄今为止限制了癌症疫苗的应用。本文通过简便的一锅法制备了包含卵清蛋白（OVA）、MnO 和聚多巴胺（OMPN）的多功能纳米疫苗。OMPN 对原位黑色素瘤具有优异的抗癌疗效，并且可以在肿瘤再挑战小鼠模型中预防肝转移。此外，通过 MRI 对比 OMPN 对接种后腹股沟淋巴结中 DC 迁移行为进行了跟踪，表明 DC 成功激活和免疫反应。优异的抗癌疗效，尤其是对肿瘤转移的高效性，以及跟踪免疫接种过程的能力，使 OMPN 成为一种很有前途的多功能纳米癌症治疗疫苗。
