Department of Fisheries and Biology, Persian Gulf Research Institute, Persian Gulf University, Bushehr, Iran.
Institute of Ichthyobiology and Aquaculture in Gołysz, Polish Academy of Sciences, Kalinowa 2, 43-520, Chybie, Poland.
Probiotics Antimicrob Proteins. 2021 Dec;13(6):1790-1797. doi: 10.1007/s12602-021-09805-4. Epub 2021 May 25.
The aim of this study was to evaluate the effects of lactoferrin (Lf) on growth and feeding performance, biochemical and immune parameters in Asian sea bass (Lates calcarifer). A basal diet was supplemented with 0 (control), 400 (400 Lf), or 800 (800 Lf) mg Lf kg diet. The results indicate a significant increase in innate immune parameters when the diet was supplemented with 800 mg Lf kg. The highest serum albumin value and the lowest serum glucose concentration were observed in 800 Lf group. The liver catalase activity in the 400 Lf and 800 Lf groups was lower than the control value. Moreover, malondialdehyde concentration in the liver of Asian sea bass was increased with increasing the dietary Lf supplementation. The results of the study suggest that supplementing diet with 800 mg Lf kg stimulates non-specific immune response in Asian sea bass. Nonetheless, selecting an appropriate dose can be difficult, especially since both the higher and the lower dose tested may result in adverse effects.
本研究旨在评估乳铁蛋白（Lf）对尖吻鲈生长和摄食性能、生化和免疫参数的影响。在基础饲料中分别添加 0（对照组）、400（400Lf）或 800（800Lf）mg/kg 饲料的 Lf。结果表明，当饲料中添加 800mg/kgLf 时，先天免疫参数显著增加。800Lf 组血清白蛋白值最高，血清葡萄糖浓度最低。400Lf 和 800Lf 组的肝过氧化氢酶活性低于对照组。此外，随着饲料中 Lf 补充量的增加，尖吻鲈肝脏中的丙二醛浓度增加。研究结果表明，在饲料中添加 800mg/kgLf 可刺激尖吻鲈的非特异性免疫反应。然而，选择合适的剂量可能很困难，特别是因为测试的较高和较低剂量都可能产生不良反应。
