Academic Unit of Veterinary Medicine, Autonomous University of Zacatecas, Zacatecas, Mexico.
Medical Research Unit-Zacatecas, Mexican Institute for Social Security- IMSS, Zacatecas, Mexico.
Peptides. 2021 Aug;142:170576. doi: 10.1016/j.peptides.2021.170576. Epub 2021 May 24.
Antimicrobial peptides (AMPs) are molecules with a broad-spectrum activity against bacteria, fungi, protozoa, and viruses. These peptides are widely distributed in insects, amphibians and mammals. Indeed, they are key molecules of the innate immune system with remarkable antimicrobial and immunomodulatory activity. Besides, these peptides have also shown regulatory activity for gut microbiota and have been considered inductors of growth performance. The current review describes the updated findings of antimicrobial peptides in domestic animals, such as bovines, goats, sheep, pigs, horses, canines and felines, analyzing the most relevant aspects of their use as potential therapeutics and their applications in Veterinary medicine.
抗菌肽（AMPs）是一类对细菌、真菌、原生动物和病毒具有广谱活性的分子。这些肽广泛分布于昆虫、两栖动物和哺乳动物中。事实上，它们是先天免疫系统的关键分子，具有显著的抗菌和免疫调节活性。此外，这些肽对肠道微生物群也具有调节活性，并被认为是生长性能的诱导剂。本综述描述了抗菌肽在牛、山羊、绵羊、猪、马、犬和猫等家畜中的最新研究发现，分析了它们作为潜在治疗剂的应用的最相关方面及其在兽医领域的应用。
