Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil.
Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil; Programa de Pós-Graduação em Ciências da Saúde, Universidade de Brasília, Brasília, Distrito Federal, Brazil; Curso de Odontologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil.
Drug Discov Today. 2021 Aug;26(8):2064-2074. doi: 10.1016/j.drudis.2021.03.008. Epub 2021 Mar 16.
Microbial infections are a major worldwide public health problem because a number of microorganisms can show drug resistance. Antimicrobial peptides (AMPs) are small biomolecules that present antimicrobial and immunomodulatory activities. Despite their great potential, there are still many barriers to the formulation of these molecules. In this context, nanotechnological approaches such as nanofibers are candidate drug-delivery systems for AMP formulations. These nanomaterials have a large contact surface and may carry several AMPs (single or multilayer), directing them to specific targets. Thus, this review describes the main advances related to the use of nanofibers as drug-delivery systems for AMPs. These strategies can contribute directly to the design of new multifunctional wound dressings, coatings for prostheses, and tissue engineering applications.
微生物感染是一个全球性的主要公共卫生问题，因为许多微生物都可能表现出耐药性。抗菌肽（AMPs）是具有抗菌和免疫调节活性的小分子生物分子。尽管它们有很大的潜力，但这些分子的制剂仍然存在许多障碍。在这种情况下，纳米技术方法（如纳米纤维）是 AMP 制剂的候选药物输送系统。这些纳米材料具有较大的接触表面，并且可以携带几种 AMP（单层或多层），将它们靶向特定的目标。因此，本综述描述了与使用纳米纤维作为 AMP 的药物输送系统相关的主要进展。这些策略可以直接有助于设计新型多功能伤口敷料、假体涂层和组织工程应用。
