Department of Central Laboratory, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang, Liaoning, China.
Department of Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang, Liaoning, China.
J Int Med Res. 2021 May;49(5):3000605211014803. doi: 10.1177/03000605211014803.
Ameloblastoma is a common odontogenic epithelial tumor that exhibits various biological behaviors, ranging from simple cystic expansion to aggressive solid masses characterized by local invasiveness, a high risk of recurrence, and even malignant transformation. We report on two cases of unusually large solid ameloblastomas. We detected epithelial-mesenchymal transition-related gene expression and gene single nucleotide polymorphisms, providing possible molecular evidence of mesenchymal morphological changes in ameloblastoma. The detailed analysis of the pathogenesis of these two cases of ameloblastoma may deepen our understanding of this rare disease and offer promising targets for future targeted therapy.
成釉细胞瘤是一种常见的牙源性上皮性肿瘤，具有多种生物学行为，从单纯的囊状扩张到侵袭性实体肿块，局部侵袭性高，复发风险高，甚至恶性转化。我们报告了两例非常大的成釉细胞瘤实体瘤病例。我们检测了上皮-间充质转化相关基因的表达和基因单核苷酸多态性，为成釉细胞瘤中间充质形态变化的可能分子证据提供了依据。对这两例成釉细胞瘤发病机制的详细分析，可能加深我们对这种罕见疾病的认识，并为未来的靶向治疗提供有希望的靶点。
