• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

托吡酯对乙醇所致大鼠胃溃疡的胃保护作用。

Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats.

作者信息

Kadasah Saeed, Al Eid Ahmad Saleh, Alawad Salem Saleh, Al Shahrani Abdullah S, Alruwaihi Ahmed Salem, Elfaki Ibrahim, Arshaduddin Mohammed

机构信息

Department of Psychiatry, PSMMC, Riyadh, Saudi Arabia.

Department of Pharmacy, PSMMC, Riyadh, Saudi Arabia.

出版信息

Toxicol Rep. 2021 May 11;8:1031-1039. doi: 10.1016/j.toxrep.2021.05.004. eCollection 2021.

DOI:10.1016/j.toxrep.2021.05.004
PMID:34036049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8138487/
Abstract

BACKGROUND

Topiramate (TPM), an antiepileptic drug, is also effective against alcohol dependency, a crucial factor in forming gastric ulcers. There is an increased possibility of patients with compromised gastric conditions getting exposed to TPM, but its effect on gastric ulcers is unknown. This study investigates the implication of acute TPM in ethanol-produced gastric ulceration in rats.

MATERIAL AND METHODS

The effect of TPM studied in male 200-225 g Sprague Dawley rats against ethanol-induced gastric ulcers and for gastric secretion and acidity. The factors assessed include gastric secretion and acidity, gastric ulcer score, biochemical and histological changes, NF-kB, and p53 expression. The analysis of data performed by using the Kruskal Wallis test and Dunnett's multiple comparison tests.

RESULTS

TPM pretreatment showed gastroprotective effects. It significantly reduced ethanol-induced increased gastric secretion, acidity, and gastric ulcer index and prevented gastric mucus depletion. The ethanol-induced inflammation and apoptosis were also significantly decreased by reducing the increased gastric myeloperoxidase activity and the expression of NF-kB and p53. TPM pretreatment also reduced the ethanol-induced damage to the gastric histology in rats.

CONCLUSION

TPM exerted a gastro-protective effect against ethanol-induced gastric ulcers mediated by reducing the gastric ulcer index, preventing a decrease of the mucus levels, reduction in inflammation, damage to gastric histology, and a decrease in the enhanced expression of NF-kB and TPM. Further detailed investigations are essential to understand the chronic influence of TPM on gastric ulcers.

摘要

背景

托吡酯（TPM）是一种抗癫痫药物，对酒精依赖也有效，而酒精依赖是形成胃溃疡的关键因素。胃部状况不佳的患者接触TPM的可能性增加，但其对胃溃疡的影响尚不清楚。本研究调查急性TPM对大鼠乙醇诱导的胃溃疡的影响。

材料与方法

在体重200 - 225 g的雄性Sprague Dawley大鼠中研究TPM对乙醇诱导的胃溃疡以及胃分泌和酸度的影响。评估的因素包括胃分泌和酸度、胃溃疡评分、生化和组织学变化、NF-κB和p53表达。使用Kruskal Wallis检验和Dunnett多重比较检验进行数据分析。

结果

TPM预处理显示出胃保护作用。它显著降低了乙醇诱导的胃分泌增加、酸度和胃溃疡指数，并防止了胃黏液减少。通过降低胃髓过氧化物酶活性以及NF-κB和p53的表达增加，乙醇诱导的炎症和细胞凋亡也显著减少。TPM预处理还减少了乙醇对大鼠胃组织学的损伤。

结论

TPM通过降低胃溃疡指数、防止黏液水平降低、减轻炎症、减少胃组织学损伤以及降低NF-κB和TPM增强表达介导的乙醇诱导的胃溃疡，发挥了胃保护作用。进一步详细研究对于了解TPM对胃溃疡的慢性影响至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/a7b8c74af8a7/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/7df71cc82a0b/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/7e620c5750cf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/be3ec418eaee/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/b4724585f2a3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/07d360cba9ba/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/dedbf5554ed5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/e6dbbe9f4d18/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/fa51448db42e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/a7b8c74af8a7/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/7df71cc82a0b/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/7e620c5750cf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/be3ec418eaee/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/b4724585f2a3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/07d360cba9ba/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/dedbf5554ed5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/e6dbbe9f4d18/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/fa51448db42e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a31b/8138487/a7b8c74af8a7/gr8.jpg

相似文献

1
Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats.托吡酯对乙醇所致大鼠胃溃疡的胃保护作用。
Toxicol Rep. 2021 May 11;8:1031-1039. doi: 10.1016/j.toxrep.2021.05.004. eCollection 2021.
2
Aripiprazole an atypical antipsychotic protects against ethanol induced gastric ulcers in rats.阿立哌唑，一种非典型抗精神病药物，可预防大鼠乙醇诱导的胃溃疡。
Int J Clin Exp Med. 2014 Aug 15;7(8):2031-44. eCollection 2014.
3
Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation.香草醛通过调节胃分泌、氧化应激和炎症减轻乙醇诱导的大鼠胃损伤。
Toxicol Rep. 2015 Dec 12;3:105-113. doi: 10.1016/j.toxrep.2015.11.001. eCollection 2016.
4
Gastroprotective effect of minocycline in experimentally induced gastric ulcers in rats.米诺环素对大鼠实验性胃溃疡的胃保护作用。
Int J Clin Exp Med. 2014 Mar 15;7(3):586-96. eCollection 2014.
5
Gastric antisecretory and antiulcer activity of bovine hemoglobin.牛血红蛋白的胃抑酸和抗溃疡活性。
World J Gastroenterol. 2013 Jun 7;19(21):3291-9. doi: 10.3748/wjg.v19.i21.3291.
6
Gastroprotective effects of thymol on acute and chronic ulcers in rats: The role of prostaglandins, ATP-sensitive K(+) channels, and gastric mucus secretion.百里香酚对大鼠急性和慢性溃疡的胃保护作用：前列腺素、ATP敏感性钾通道及胃黏液分泌的作用
Chem Biol Interact. 2016 Jan 25;244:121-8. doi: 10.1016/j.cbi.2015.12.004. Epub 2015 Dec 13.
7
Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role.芥子酸对乙醇诱导的大鼠胃溃疡的胃保护作用：Nrf2/HO-1和NF-κB信号通路的参与及抗凋亡作用
Front Pharmacol. 2021 Feb 25;12:622815. doi: 10.3389/fphar.2021.622815. eCollection 2021.
8
Gastro-protective, therapeutic and anti-inflammatory activities of Pistacia lentiscus L. fatty oil against ethanol-induced gastric ulcers in rats.松属黄连木脂肪酸油对乙醇诱导的大鼠胃溃疡的胃保护、治疗和抗炎作用。
J Ethnopharmacol. 2018 Oct 5;224:273-282. doi: 10.1016/j.jep.2018.05.040. Epub 2018 May 31.
9
Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats.广藿香醇对大鼠乙醇、吲哚美辛和应激性溃疡的胃保护作用及机制
Chem Biol Interact. 2014 Oct 5;222:27-36. doi: 10.1016/j.cbi.2014.08.008. Epub 2014 Aug 26.
10
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role.没食子酸对乙醇诱导的大鼠胃溃疡的胃保护作用：涉及 Nrf2/HO-1 信号通路和抗细胞凋亡作用。
Biomed Pharmacother. 2020 Jun;126:110075. doi: 10.1016/j.biopha.2020.110075. Epub 2020 Mar 13.

引用本文的文献

1
Topiramate Attenuates Cadmium-Induced Nephrotoxicity Through Modulation of Oxidative Stress, Autophagy, and Apoptosis in Rats.托吡酯通过调节大鼠的氧化应激、自噬和凋亡减轻镉诱导的肾毒性。
Biol Trace Elem Res. 2025 Jul 11. doi: 10.1007/s12011-025-04736-5.
2
Innovative approaches for beetroot (Beta Vulgaris L.) aqueous extraction by cyclodextrins and its use to alleviate ethanol induced gastric ulcer in rats.环糊精用于甜菜根（Beta Vulgaris L.）水提取的创新方法及其在减轻大鼠乙醇诱导胃溃疡中的应用。
Saudi Pharm J. 2025 Apr 16;33(1-2):2. doi: 10.1007/s44446-025-00008-4.
3
Chemical Composition and Antiulcer Effects of Filipendula palmata in Mice.

本文引用的文献

1
Correction: Anti-ulcerogenic effect of KFP-H008 against ethanol-induced gastric ulcer p38 MAPK/NF-κB pathway.更正：KFP-H008对乙醇诱导的胃溃疡的抗溃疡作用及p38丝裂原活化蛋白激酶/核因子κB信号通路
RSC Adv. 2019 Jun 4;9(31):17591. doi: 10.1039/c9ra90042j.
2
Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice.蜗牛分泌滤液对小鼠乙醇性胃溃疡的保护作用。
Sci Rep. 2021 Feb 11;11(1):3638. doi: 10.1038/s41598-021-83170-8.
3
Seed Extract Attenuates the Ethanol-Induced Gastric Ulcer in Rats via the Inhibition of TNF- and INF- Levels and Modulation in the Expression of Ki67 Protein.
手掌叶蚊子草的化学成分及其对小鼠的抗溃疡作用
Plant Foods Hum Nutr. 2025 Feb 4;80(1):56. doi: 10.1007/s11130-024-01286-4.
4
Gastroprotective effect of vanillic acid against ethanol-induced gastric injury in rats: involvement of the NF-κB signalling and anti-apoptosis role.香草酸对乙醇诱导的大鼠胃损伤的胃保护作用：涉及 NF-κB 信号通路和抗细胞凋亡作用。
Mol Biol Rep. 2024 Jun 14;51(1):744. doi: 10.1007/s11033-024-09672-6.
5
Topiramate Reprofiling for the Attenuation of Cadmium-Induced Testicular Impairment in Rats: Role of NLRP3 Inflammasome and AMPK/mTOR-Linked Autophagy.托吡酯重新定位用于减轻镉诱导的大鼠睾丸损伤：NLRP3炎性小体和AMPK/mTOR相关自噬的作用
Pharmaceuticals (Basel). 2022 Nov 14;15(11):1402. doi: 10.3390/ph15111402.
6
The Promising Effect of Topiramate on Random-Pattern Skin Flap Survival in Rats.托吡酯对大鼠随意皮瓣成活率的影响。
Aesthetic Plast Surg. 2022 Oct;46(5):2548-2555. doi: 10.1007/s00266-022-02969-6. Epub 2022 Jun 17.
7
Gastroprotective and Antioxidative Effects of the Traditional Thai Polyherbal Formula Phy-Blica-D against Ethanol-Induced Gastric Ulcers in Rats.泰国传统复方草药 Phy-Blica-D 对乙醇诱导的大鼠胃溃疡的胃保护和抗氧化作用。
Nutrients. 2021 Dec 30;14(1):172. doi: 10.3390/nu14010172.
种子提取物通过抑制 TNF-α 和 IFN-γ 水平以及调节 Ki67 蛋白表达来减轻乙醇诱导的大鼠胃溃疡。
Biomed Res Int. 2021 Jan 11;2021:6694572. doi: 10.1155/2021/6694572. eCollection 2021.
4
Formulation, optimization and characterization of allantoin-loaded chitosan nanoparticles to alleviate ethanol-induced gastric ulcer: in-vitro and in-vivo studies.载尿囊素壳聚糖纳米粒的处方前研究、优化及其体内外评价用于缓解乙醇诱导的胃溃疡
Sci Rep. 2021 Jan 26;11(1):2216. doi: 10.1038/s41598-021-81183-x.
5
Anti-Ulcerogenic and Cytoprotective Effects of Saharian (Sidr) Honey from Algeria.阿尔及利亚撒哈拉（锡德）蜂蜜的抗溃疡和细胞保护作用。
Comb Chem High Throughput Screen. 2021;24(10):1664-1670. doi: 10.2174/1386207323999201117114008.
6
Topiramate Reduces Aortic Cross-Clamping-Induced Lung Injury in Male Rats.托吡酯减轻雄性大鼠主动脉夹闭诱导的肺损伤。
Acta Medica (Hradec Kralove). 2018;61(4):144-149. doi: 10.14712/18059694.2018.133.
7
Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice.抗癫痫药物（托吡酯）和冷榨姜油对小鼠睾丸基因表达、性激素和组织病理学改变的影响。
Biomed Pharmacother. 2019 Feb;110:409-419. doi: 10.1016/j.biopha.2018.11.146. Epub 2018 Dec 5.
8
Diagnosis and Pharmacotherapy of Alcohol Use Disorder: A Review.酒精使用障碍的诊断与药物治疗：综述。
JAMA. 2018 Aug 28;320(8):815-824. doi: 10.1001/jama.2018.11406.
9
National Cancer Societies and their public statements on alcohol consumption and cancer risk.国家癌症协会及其关于饮酒与癌症风险的公开声明。
Addiction. 2018 Oct;113(10):1802-1808. doi: 10.1111/add.14254. Epub 2018 May 31.
10
Effects of topical topiramate in wound healing in mice.局部应用托吡酯对小鼠伤口愈合的影响。
Arch Dermatol Res. 2018 May;310(4):363-373. doi: 10.1007/s00403-018-1822-z. Epub 2018 Feb 23.