Correa-Gallegos Donovan, Jiang Dongsheng, Rinkevich Yuval
Institute of Lung Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum München, Munich, Germany.
Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, Germany.
Immunol Rev. 2021 Jul;302(1):147-162. doi: 10.1111/imr.12972. Epub 2021 May 25.
Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in the mammalian body. This cellular variety impacts the spectrum of responses elicited by the immune system. Fibroblast influence on the immune system keeps evolving our perspective on fibroblast roles and functions beyond just a passive structural part of organs. This review discusses the foundations of fibroblastic stromal-immune crosstalk, under the scope of stromal heterogeneity as a basis for tissue-specific tutoring of the immune system. Focusing on the skin as a relevant immunological organ, we detail the complex interactions between distinct fibroblast populations and immune cells that occur during homeostasis, injury repair, scarring, and disease. We further review the relevance of fibroblastic stromal cell heterogeneity and how this heterogeneity is central to regulate the immune system from its inception during embryonic development into adulthood.
成纤维细胞性基质细胞在起源和功能上与它们在哺乳动物体内构建的生态位一样多样。这种细胞多样性影响免疫系统引发的反应谱。成纤维细胞对免疫系统的影响不断改变我们对成纤维细胞作用和功能的看法，其作用已不仅仅是器官的被动结构部分。本综述在基质异质性作为免疫系统组织特异性指导基础的范围内，讨论了成纤维细胞性基质 - 免疫相互作用的基础。以皮肤作为一个相关的免疫器官为例，我们详细阐述了在稳态、损伤修复、瘢痕形成和疾病过程中，不同成纤维细胞群体与免疫细胞之间发生的复杂相互作用。我们还回顾了成纤维细胞性基质细胞异质性的相关性，以及这种异质性如何在从胚胎发育到成年的过程中，从免疫系统起源开始就对其调节起着核心作用。
