Infection Biology, Department of Biotechnology, Central University of Tamil Nadu, Thiruvarur, India.
Laboratory Centre, Xiamen University Malaysia, Sepang, Selangor, Malaysia.
Viral Immunol. 2023 Jan;36(1):55-62. doi: 10.1089/vim.2022.0144. Epub 2022 Nov 10.
Scientific observations indicate that an actively prevailing systemic condition could alleviate the pathology of another disease. Human pegivirus (HPgV), a highly ubiquitous flavivirus is believed to be associated with slow human immunodeficiency virus (HIV) disease progression, and has seldom been linked to hepatic pathology. In this study, we investigated whether HPgV seropositivity had any impact on surrogate markers of HIV disease progression in a cohort of HIV-infected HPgV seropositive ( = 28) and seronegative ( = 12) individuals who were prospectively evaluated for absolute CD4+ T cell counts, plasma viral load (PVL), liver enzymes, and plasma cytokine levels. The HIV PVL was relatively lower in HPgV seropositive than in HPgV seronegative HIV-infected subjects. Clinical markers of hepatic injury were significantly low among HPgV seropositive HIV-infected participants. HPgV seropositive individuals showed significantly higher levels of interleukin-7 (IL-7), and although not significant, the levels of IL-6 were lower among HPgV seropositive subjects. Spearman correlation analysis showed that the absolute CD4+T cell count was inversely correlated with HIV PVL. Exposure to HPgV appears to have a positive prognostic impact on the levels of surrogate biomarkers of HIV disease progression.
科学观察表明，一种普遍存在的系统性疾病可能会减轻另一种疾病的病理。人类戊型肝炎病毒（HPgV）是一种高度普遍存在的黄病毒，据信与人类免疫缺陷病毒（HIV）疾病的缓慢进展有关，并且很少与肝病理有关。在这项研究中，我们调查了在一组 HIV 感染的 HPgV 血清阳性（=28）和血清阴性（=12）个体中，HPgV 血清阳性是否对 HIV 疾病进展的替代标志物有任何影响，这些个体前瞻性地评估了绝对 CD4+T 细胞计数、血浆病毒载量（PVL）、肝酶和血浆细胞因子水平。与 HPgV 血清阴性的 HIV 感染者相比，HPgV 血清阳性者的 HIV PVL 相对较低。在感染 HIV 的 HPgV 血清阳性者中，肝损伤的临床标志物明显较低。HPgV 血清阳性者的白细胞介素-7（IL-7）水平明显较高，尽管没有统计学意义，但 HPgV 血清阳性者的 IL-6 水平较低。Spearman 相关分析显示，绝对 CD4+T 细胞计数与 HIV PVL 呈负相关。暴露于 HPgV 似乎对 HIV 疾病进展替代生物标志物的水平具有积极的预后影响。
