Chen Lin, Ru Qin, Xiong Qi, Zhou Mei, Yue Kai, Wu Yuxiang
Department of Health and Physical Education, Jianghan University, Wuhan, China.
Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan, China.
Front Pharmacol. 2021 May 10;12:679905. doi: 10.3389/fphar.2021.679905. eCollection 2021.
Repeated intake of methamphetamine (METH) leads to drug addiction, the inability to control intake, and strong drug cravings. It is also likely to cause psychiatric impairments, such as cognitive impairment, depression, and anxiety. Because the specific neurobiological mechanisms involved are complex and have not been fully and systematically elucidated, there is no established pharmacotherapy for METH abuse. Studies have found that a variety of Chinese herbal medicines have significant therapeutic effects on neuropsychiatric symptoms and have the advantage of multitarget comprehensive treatment. We conducted a systematic review, from neurobiological mechanisms to candidate Chinese herbal medicines, hoping to provide new perspectives and ideas for the prevention and treatment of METH abuse.
反复摄入甲基苯丙胺（METH）会导致药物成瘾、无法控制摄入量以及强烈的药物渴望。它还可能导致精神障碍，如认知障碍、抑郁和焦虑。由于所涉及的具体神经生物学机制复杂且尚未得到充分系统的阐明，目前尚无针对甲基苯丙胺滥用的确立药物疗法。研究发现，多种中草药对神经精神症状具有显著治疗作用，且具有多靶点综合治疗的优势。我们进行了一项从神经生物学机制到候选中草药的系统综述，希望为甲基苯丙胺滥用的预防和治疗提供新的视角和思路。
