新冠康复：短跑还是马拉松？来自线上新冠长期症状支持小组成员的6个月随访数据。
Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members.
作者信息
Vaes Anouk W, Goërtz Yvonne M J, Van Herck Maarten, Machado Felipe V C, Meys Roy, Delbressine Jeannet M, Houben-Wilke Sarah, Gaffron Swetlana, Maier Dieter, Burtin Chris, Posthuma Rein, van Loon Nicole P H, Franssen Frits M E, Hajian Bita, Simons Sami O, van Boven Job F M, Klok Frederikus A, Spaetgens Bart, Pinxt Claire M H, Liu Limmie Y L, Wesseling Geertjan, Spies Yvonne, Vijlbrief Herman, van 't Hul Alex J, Janssen Daisy J A, Spruit Martijn A
机构信息
Dept of Research and Development, Ciro, Horn, The Netherlands.
Nutrim School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands.
出版信息
ERJ Open Res. 2021 May 24;7(2). doi: 10.1183/23120541.00141-2021. eCollection 2021 Apr.
BACKGROUND
It remains unknown whether and to what extent members of online "long COVID" peer support groups remain symptomatic and limited over time. Therefore, we aimed to evaluate symptoms in members of online long COVID peer support groups up to 6 months after the onset of coronavirus disease 2019 (COVID-19)-related symptoms.
METHODS
Demographics, symptoms, health status, work productivity, functional status and health-related quality of life were assessed about 3 and 6 months after the onset of COVID-19-related symptoms in members of online long COVID peer support groups.
RESULTS
Data from 239 patients with a confirmed COVID-19 diagnosis (83% women; median (interquartile range) age 50 (39-56) years) were analysed. During the infection, a median (interquartile range) of 15 (11-18) symptoms was reported, which was significantly lower 3 and 6 months later: 6 (4-9) and 6 (3-8), respectively (p<0.05). From 3 to 6 months follow-up, the proportion of patients without symptoms increased from 1.3% to only 5.4% (p<0.001). Patients also reported a significantly improved work productivity (work absenteeism and presenteeism: 73% 52% and 66% 60%, respectively), self-reported good health (9.2% 16.7%), functional status (mean±sd Post-COVID-19 Functional Status scale: 2.4±0.9 2.2±1.0) and health-related quality of life (all p<0.05).
CONCLUSION
Although patients with confirmed COVID-19, who were all members of online long COVID peer support groups, reported significant improvements in work productivity, functional status and quality of life between 3 and 6 months follow-up, these data clearly highlight the long-term impact of COVID-19, as approximately 6 months after the onset of COVID-19-related symptoms a large proportion still experienced persistent symptoms, a moderate-to-poor health, moderate-to-severe functional limitations, considerable loss in work productivity, and/or an impaired quality of life. Action is needed to improve the management and healthcare of these patients.
背景
线上“长新冠”病友互助小组的成员症状是否会持续以及在何种程度上持续，目前仍不清楚。因此，我们旨在评估线上长新冠病友互助小组的成员在新型冠状病毒肺炎（COVID-19）相关症状出现后长达6个月的症状情况。
方法
对线上长新冠病友互助小组的成员在出现COVID-19相关症状后约3个月和6个月时的人口统计学特征、症状、健康状况、工作效率、功能状态及与健康相关的生活质量进行评估。
结果
分析了239例确诊COVID-19患者的数据（83%为女性；年龄中位数（四分位间距）为50（39 - 56）岁）。在感染期间，报告的症状中位数（四分位间距）为15（11 - 18）个，但在3个月和6个月后显著减少，分别为6（4 - 9）个和6（3 - 8）个（p<0.05）。从3个月到6个月的随访中，无症状患者的比例从1.3%仅增加到5.4%（p<0.001）。患者还报告工作效率显著提高（旷工和出勤时的工作效率：分别从73%提高到52%，从66%提高到60%），自我报告的健康状况良好（从9.2%提高到16.7%），功能状态（COVID-19后功能状态量表均值±标准差：从2.4±0.9提高到2.2±1.0）以及与健康相关的生活质量（所有p<0.05）。
结论
尽管所有确诊COVID-19且属于线上长新冠病友互助小组的患者在3至6个月的随访期间工作效率、功能状态和生活质量有显著改善，但这些数据清楚地凸显了COVID-19的长期影响，因为在COVID-19相关症状出现约6个月后，仍有很大比例的患者经历持续症状、中重度健康问题、中度至重度功能受限、工作效率大幅下降和/或生活质量受损。需要采取行动来改善这些患者的管理和医疗护理。
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