Physiology and Biomedical Engineering, Mayo Clinic College of Medicine & Science, 200 First Street SW, Rochester, MN 55905, USA.
Physiology and Biomedical Engineering, Mayo Clinic College of Medicine & Science, 200 First Street SW, Rochester, MN 55905, USA; University of Minnesota-Rochester, 111 South Broadway, Suite 300, Rochester, MN 55904, USA.
Curr Opin Insect Sci. 2021 Oct;47:82-89. doi: 10.1016/j.cois.2021.05.003. Epub 2021 May 24.
The insect renal (Malpighian) tubules are functionally homologous to the mammalian kidney. Accumulating evidence indicates that renal tubule crystals form in a manner similar to mammalian kidney stones. In Drosophila melanogaster, crystals can be induced by diet, toxic substances, or genetic mutations that reflect circumstances influencing or eliciting kidney stones in mammals. Incredibly, many mammalian proteins have distinct homologs in Drosophila, and the function of most homologs have been demonstrated to recapitulate their mammalian and human counterparts. Here, we discuss the present literature establishing Drosophila as a nephrolithiasis model. This insect model may be used to investigate and understand the etiology of kidney stone diseases, especially with regard to calcium oxalate, calcium phosphate and xanthine or urate crystallization.
昆虫的肾（马氏管）小管在功能上与哺乳动物的肾脏同源。越来越多的证据表明，肾小管晶体的形成方式与哺乳动物的肾结石相似。在黑腹果蝇中，晶体可以通过饮食、有毒物质或遗传突变来诱导，这些因素反映了影响或引发哺乳动物肾结石的情况。令人难以置信的是，许多哺乳动物蛋白在果蝇中有明显的同源物，并且大多数同源物的功能已被证明与其哺乳动物和人类的对应物相吻合。在这里，我们讨论了目前将果蝇确立为肾结石模型的文献。这种昆虫模型可用于研究和了解肾结石疾病的病因，特别是涉及草酸钙、磷酸钙和黄嘌呤或尿酸结晶的情况。
