Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518055, China.
Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, 518055, China.
ACS Sens. 2021 Jun 25;6(6):1990-2001. doi: 10.1021/acssensors.1c00756. Epub 2021 May 28.
Hydrogel is a unique family of biocompatible materials with growing applications in chemical and biological sensors. During the past few decades, various hydrogel-based optical ion sensors have been developed aiming at point-of-care testing and environmental monitoring. In this Perspective, we provide an overview of the research field including topics such as photonic crystals, DNAzyme cross-linked hydrogels, ionophore-based ion sensing hydrogels, and fluoroionophore-based optodes. As the different sensing principles are summarized, each strategy offers its advantages and limitations. In a nutshell, developing optical ion sensing hydrogels is still in the early stage with many opportunities lying ahead, especially with challenges in selectivity, assay time, detection limit, and usability.
水凝胶是一类独特的生物相容性材料，在化学和生物传感器领域的应用日益广泛。在过去的几十年中，各种基于水凝胶的光学离子传感器已经被开发出来，旨在用于即时检测和环境监测。在本观点文章中，我们综述了这一研究领域，包括光子晶体、DNA zyme 交联水凝胶、离子载体基离子传感水凝胶和荧光离子对基光导纤维等主题。不同的传感原理被总结后，每种策略都有其优点和局限性。简而言之，开发光学离子传感水凝胶仍处于早期阶段，有许多机会有待挖掘，尤其是在选择性、分析时间、检测限和可用性方面存在挑战。
