Terfassi Siham, Dauvergne Xavier, Cérantola Stéphane, Lemoine Clément, Bensouici Chawki, Fadila Benayache, Christian Magné, Marchioni Eric, Benayache Samir
Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques, Université des Frères Mentouri, Constantine, Algeria.
EA 7462 Géoarchitecture_Territoires, Urbanisation, Biodiversité, Environnement, Université de Bretagne Occidentale, Brest Cedex 3, France.
Nat Prod Res. 2022 Jun;36(11):2806-2813. doi: 10.1080/14786419.2021.1928664. Epub 2021 May 27.
A new flavonoid, 5,7,2',4',5'-pentahydroxyflavone 3--β-D-galactopyranoside ( and twelve known derivatives: an aryltetralin-lignan (, seven flavonoids (, , ) and four phenolic acids (, , ) have been isolated from the aerial parts of Pomel. ( family) an endemic species to the septentrional Sahara that is being studied for the first time. Structure elucidation of the isolated compounds was established by means of spectroscopic methods especially NMR and Mass Spectrometry. antioxidant (DPPH, ABTS, GOR and CUPRAC assays) and antidiabetic (micro-dilution method) activities of the crude extract, fractions and isolated compounds were performed. The new flavonol ( and Compounds (, , , were found to be the most active, some of them exhibiting better activity than the antioxidant standards. Compounds , and showed higher α-glucosidase inhibitory activity compared to standard acarbose (IC= 2.70 ± 0.03 µM, 3.09 ± 0.03 µM, 37.28 ± 1.20 µM and 275.43 ± 1.59 µM, respectively).
一种新的黄酮类化合物，5,7,2',4',5'-五羟基黄酮3--β-D-吡喃半乳糖苷（以及十二种已知衍生物：一种芳基四氢萘-木脂素（、七种黄酮类化合物（、、）和四种酚酸（、、）已从Pomel.（菊科）的地上部分分离得到，Pomel.是撒哈拉北部的一种特有物种，这是首次对其进行研究。通过光谱方法，特别是核磁共振和质谱法对分离出的化合物进行结构解析。对粗提取物、馏分和分离出的化合物进行了抗氧化（DPPH、ABTS、GOR和CUPRAC测定）和抗糖尿病（微量稀释法）活性测试。发现新的黄酮醇（和化合物（、、、）活性最强，其中一些表现出比抗氧化标准品更好的活性。与标准阿卡波糖相比，化合物、和表现出更高的α-葡萄糖苷酶抑制活性（IC分别为2.70 ± 0.03 µM、3.09 ± 0.03 µM、37.28 ± 1.20 µM和275.43 ± 1.59 µM）。
