首次使用物质的年龄与大麻使用及大麻使用障碍的持续存在之间的关系。
Relationships between age at first substance use and persistence of cannabis use and cannabis use disorder.
作者信息
Millar Seán R, Mongan Deirdre, Smyth Bobby P, Perry Ivan J, Galvin Brian
机构信息
Health Research Board, Grattan House 67-72 Lower Mount Street, Dublin, Ireland.
School of Public Health, University College Cork, 4th Floor, Western Gateway Building, Cork, Ireland.
出版信息
BMC Public Health. 2021 May 27;21(1):997. doi: 10.1186/s12889-021-11023-0.
BACKGROUND
From a secondary prevention perspective, it is useful to know who is at greatest risk of progressing from substance initiation to riskier patterns of future use. Therefore, the aim of this study was to determine relationships between age at first use of alcohol, tobacco and cannabis and patterns of cannabis use, frequency of use and whether age of substance use onset is related to having a cannabis use disorder (CUD).
METHODS
We analysed data from Ireland's 2010/11 and 2014/15 National Drug Prevalence Surveys, which recruited 5134 and 7005 individuals respectively, aged 15 years and over, living in private households. We included only those people who reported lifetime cannabis use. Multinomial, linear and binary logistic regression analyses were used to determine relationships between age of substance use onset and patterns of cannabis use, frequency of use and having a CUD.
RESULTS
When compared to former users, the odds of being a current cannabis user were found to be reduced by 11% (OR = 0.89; 95% CI: 0.83, 0.95) and 4% (OR = 0.96; 95% CI: 0.92, 1.00) for each year of delayed alcohol and cannabis use onset, respectively. Among current users, significant inverse linear relationships were noted, with increasing age of first use of tobacco (β = - 0.547; P < .001) and cannabis (β = - 0.634; P < .001) being associated with a decreased frequency of cannabis use within the last 30 days. The odds of having a CUD were found to be reduced by 14% (OR = 0.86; 95% CI: 0.78, 0.94) and 11% (OR = 0.89; 95% CI: 0.82, 0.98) for each year of delayed tobacco and cannabis use onset respectively in analyses which examined survey participants aged 15-34 years.
CONCLUSIONS
Among people who report past cannabis use, it is those with a more precocious pattern of early use of substances, including alcohol, and especially tobacco and cannabis, who are more likely to report ongoing, heavy and problematic cannabis use. Secondary prevention initiatives should prioritise people with a pattern of very early onset substance use.
背景
从二级预防的角度来看，了解哪些人从开始使用毒品发展到未来更危险的使用模式的风险最大是很有用的。因此，本研究的目的是确定首次使用酒精、烟草和大麻的年龄与大麻使用模式、使用频率之间的关系，以及物质使用开始的年龄是否与患有大麻使用障碍（CUD）有关。
方法
我们分析了爱尔兰2010/11年和2014/15年全国药物流行率调查的数据，分别招募了5134名和7005名年龄在15岁及以上、居住在私人家庭中的个人。我们只纳入了那些报告有终生大麻使用史的人。使用多项、线性和二元逻辑回归分析来确定物质使用开始的年龄与大麻使用模式、使用频率和患有CUD之间的关系。
结果
与曾经使用者相比，酒精和大麻使用开始时间每延迟一年，当前大麻使用者的几率分别降低11%（OR = 0.89；95%CI：0.83，0.95）和4%（OR = 0.96；95%CI：0.92，1.00）。在当前使用者中，发现了显著的负线性关系，首次使用烟草（β = -0.547；P <.001）和大麻（β = -0.634；P <.001）的年龄增加与过去30天内大麻使用频率降低有关。在对15 - 34岁的调查参与者进行的分析中，烟草和大麻使用开始时间每延迟一年，患有CUD的几率分别降低14%（OR = 0.86；95%CI：0.78，0.94）和11%（OR = 0.89；95%CI：0.82，0.98）。
结论
在报告过去有大麻使用史的人群中，那些物质使用（包括酒精，尤其是烟草和大麻）较早熟的人更有可能报告持续、大量和有问题的大麻使用。二级预防措施应优先针对物质使用开始时间非常早的人群。
Zotero 插件