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自适应磁共振引导立体定向体部放射治疗:肾癌治疗的下一步。

Adaptive Magnetic Resonance-Guided Stereotactic Body Radiotherapy: The Next Step in the Treatment of Renal Cell Carcinoma.

作者信息

Keller Brian, Bruynzeel Anna M E, Tang Chad, Swaminath Anand, Kerkmeijer Linda, Chu William

机构信息

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Department of Radiation Oncology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

出版信息

Front Oncol. 2021 May 11;11:634830. doi: 10.3389/fonc.2021.634830. eCollection 2021.

Abstract

Adaptive MR-guided radiotherapy (MRgRT) is a new treatment paradigm and its role as a non-invasive treatment option for renal cell carcinoma is evolving. The early clinical experience to date shows that real-time plan adaptation based on the daily MRI anatomy can lead to improved target coverage and normal tissue sparing. Continued technological innovations will further mitigate the challenges of organ motion and enable more advanced treatment adaptation, and potentially lead to enhanced oncologic outcomes and preservation of renal function. Future applications look promising to make a positive clinical impact and further the personalization of radiotherapy in the management of renal cell carcinoma.

摘要

自适应磁共振引导放疗(MRgRT)是一种新的治疗模式,其作为肾细胞癌的非侵入性治疗选择的作用正在不断发展。迄今为止的早期临床经验表明,基于每日MRI解剖结构的实时计划调整可提高靶区覆盖范围并减少正常组织受照剂量。持续的技术创新将进一步缓解器官运动带来的挑战,并实现更先进的治疗调整,有可能提高肿瘤治疗效果并保留肾功能。未来的应用有望产生积极的临床影响,并进一步推动肾细胞癌治疗中放疗的个性化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f851/8144516/1d390e1558bd/fonc-11-634830-g001.jpg

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