扫描碳离子放射治疗前列腺癌的分次间稳健性：基于每日机房 CT 图像剂量分布的分析。
Interfractional robustness of scanning carbon ion radiotherapy for prostate cancer: An analysis based on dose distribution from daily in-room CT images.
机构信息
Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
出版信息
J Appl Clin Med Phys. 2021 Jun;22(6):130-138. doi: 10.1002/acm2.13275. Epub 2021 May 27.
PURPOSE
We analyzed interfractional robustness of scanning carbon ion radiotherapy (CIRT) for prostate cancer based on the dose distribution using daily in-room computed tomography (CT) images.
MATERIALS AND METHODS
We analyzed 11 consecutive patients treated with scanning CIRT for localized prostate cancer in our hospital between December 2015 and January 2016. In-room CT images were taken under treatment conditions in every treatment session. The dose distribution on each in-room CT image was recalculated, while retaining the pencil beam arrangement of the initial treatment plan. Then, the dose-volume histogram (DVH) parameters including the percentage of the clinical target volume (CTV) with 95% and 90% of the prescribed dose area (V95% of CTV, V90% of CTV) and V80% of rectum were calculated. The acceptance criteria for the CTV and rectum were set at V95% of CTV ≥95%, V90% of CTV ≥98%, and V80% of rectum < 10 ml.
RESULTS
V95% of CTV, V90% of CTV, and V80% of rectum for the reproduced plans were 98.8 ± 3.49%, 99.5 ± 2.15%, and 4.39 ± 3.96 ml, respectively. Acceptance of V95% of CTV, V90% of CTV, and V80% of rectum was obtained in 123 (94%), 125 (95%) and 117 sessions (89%), respectively. Acceptance of the mean dose of V95% of CTV, V90% of CTV, and V80% of rectum for each patient was obtained in 10 (91%), 10 (91%), and 11 patients (100%), respectively.
CONCLUSIONS
We demonstrated acceptable interfractional robustness based on the dose distribution in scanning CIRT for prostate cancer.
目的
我们基于使用每日治疗室内计算机断层扫描（CT）图像的剂量分布，分析前列腺癌碳离子放疗（CIRT）的分次间稳健性。
材料和方法
我们分析了 2015 年 12 月至 2016 年 1 月期间在我院接受扫描 CIRT 治疗的 11 例局限性前列腺癌患者。在每个治疗疗程中，均在治疗条件下拍摄治疗室内 CT 图像。在保留初始治疗计划的铅笔束排列的情况下，重新计算每个治疗室内 CT 图像上的剂量分布。然后，计算包括临床靶区（CTV）体积 95%和 90%处方剂量区域（CTV 体积 95%，CTV 体积 90%）和直肠 80%体积（V80%直肠）的剂量-体积直方图（DVH）参数。CTV 和直肠的接受标准设定为 CTV 体积 95%≥95%，CTV 体积 90%≥98%，直肠 80%<10ml。
结果
重现计划的 CTV 体积 95%、CTV 体积 90%和直肠 80%分别为 98.8±3.49%、99.5±2.15%和 4.39±3.96ml。123 次（94%）、125 次（95%）和 117 次（89%）分别获得了 CTV 体积 95%、CTV 体积 90%和直肠 80%的接受标准。10 例（91%）、10 例（91%）和 11 例（100%）患者的 CTV 体积 95%、CTV 体积 90%和直肠 80%的平均剂量接受标准。
结论
我们在前列腺癌扫描 CIRT 中基于剂量分布证明了可接受的分次间稳健性。
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