Department of Medicine, University of Arizona, Total Lipedema Care, Beverly Hills, CA and Tucson, AZ, USA.
The US Standard of Care Committee.
Phlebology. 2021 Dec;36(10):779-796. doi: 10.1177/02683555211015887. Epub 2021 May 28.
Lipedema is a loose connective tissue disease predominantly in women identified by increased nodular and fibrotic adipose tissue on the buttocks, hips and limbs that develops at times of hormone, weight and shape change including puberty, pregnancy, and menopause. Lipedema tissue may be very painful and can severely impair mobility. Non-lipedema obesity, lymphedema, venous disease, and hypermobile joints are comorbidities. Lipedema tissue is difficult to reduce by diet, exercise, or bariatric surgery.
This paper is a consensus guideline on lipedema written by a US committee following the Delphi Method. Consensus statements are rated for strength using the GRADE system.
Eighty-five consensus statements outline lipedema pathophysiology, and medical, surgical, vascular, and other therapeutic recommendations. Future research topics are suggested.
These guidelines improve the understanding of the loose connective tissue disease, lipedema, to advance our understanding towards early diagnosis, treatments, and ultimately a cure for affected individuals.
脂肪营养不良是一种主要发生在女性身上的疏松结缔组织疾病，其特征是臀部、臀部和四肢的结节状和纤维性脂肪组织增加，这种疾病在激素、体重和体型变化时发生，包括青春期、怀孕和更年期。脂肪营养不良组织可能非常疼痛，并严重影响活动能力。非脂肪营养不良性肥胖、淋巴水肿、静脉疾病和关节过度活动是共病。脂肪营养不良组织很难通过饮食、运动或减肥手术来减少。
本文是美国委员会按照德尔菲法制定的脂肪营养不良共识指南。使用 GRADE 系统对共识声明的强度进行评级。
85 条共识声明概述了脂肪营养不良的病理生理学以及医学、手术、血管和其他治疗建议。还提出了未来的研究课题。
这些指南提高了对疏松结缔组织疾病脂肪营养不良的理解，以促进我们对早期诊断、治疗的理解，并最终为受影响的个体找到治愈方法。
