Department of Community Medicine, University of Tromsø - The Arctic University of Norway, 9037Tromsø, Norway.
Br J Nutr. 2023 Sep 28;130(6):1047-1055. doi: 10.1017/S0007114523000077. Epub 2023 Jan 9.
According to the World Cancer Research Fund International, vitamin D might decrease the risk of colorectal cancer (CRC). However, less is known about the association with cancers in different subsites of the colon and in the rectum. The aim of this study was to examine associations between pre-diagnostic intake of vitamin D and risk of CRC by anatomical subsites. Data from 95 416 participants in the Norwegian Women and Cancer Cohort Study was included, and vitamin D intake was estimated from two repeated FFQ. Associations between vitamin D intake and incidence of CRC were assessed using multivariable Cox regression. During follow-up, there were 1774 incident cases of CRC. A small but borderline significant inverse association was found for a 5-µg increase in vitamin D intake and risk of CRC (hazard ratio (HR) = 0·97; 95 % CI 0·93, 1·01) and colon cancer (HR = 0·96; 95 % CI 0·91, 1·01). High (≥ 20 µg) compared with low (< 10 µg) vitamin D intake was associated with 17 % borderline significant reduced risk of CRC (HR = 0·83; 95 % CI 0·68, 1·02). Medium (10-19 µg) . low intake (< 10 µg) was associated with 27 % reduced risk of proximal colon cancer (HR = 0·73; 95 % CI 0·57, 0·94). No significant associations were observed between vitamin D intake and risk of distal colon or rectal cancer. Our study indicates that vitamin D may be differently associated with subsites of the colon. The association between vitamin D intake and proximal colon cancer is novel.
根据国际癌症研究基金会的数据，维生素 D 可能降低结直肠癌（CRC）的风险。然而，对于维生素 D 与结肠不同部位和直肠癌症的关联知之甚少。本研究旨在检查诊断前维生素 D 摄入量与结直肠癌解剖部位的风险之间的关联。该研究纳入了 95416 名挪威妇女与癌症队列研究的参与者，通过两份重复的 FFQ 来估计维生素 D 的摄入量。使用多变量 Cox 回归评估维生素 D 摄入量与 CRC 发生率之间的关联。在随访期间，有 1774 例 CRC 病例。研究发现，维生素 D 摄入量增加 5μg，CRC（风险比 (HR) = 0.97；95%CI 0.93，1.01）和结肠癌（HR = 0.96；95%CI 0.91，1.01）的风险呈微小但有统计学意义的负相关。与低（<10μg）维生素 D 摄入相比，高（≥20μg）维生素 D 摄入与 CRC 风险降低 17%相关（HR = 0.83；95%CI 0.68，1.02）。中（10-19μg）维生素 D 摄入与近端结肠癌风险降低 27%相关（HR = 0.73；95%CI 0.57，0.94）。维生素 D 摄入与远端结肠癌或直肠癌风险之间未观察到显著相关性。我们的研究表明，维生素 D 与结肠的不同部位可能存在不同的关联。维生素 D 摄入与近端结肠癌之间的关联是新颖的。
