牙周治疗对临床前阿尔茨海默病的影响——试验模拟方法的结果。
Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach.
机构信息
Department of Prosthetic Dentistry, Gerodontology and Biomaterials, Dental School, University Medicine Greifswald, Greifswald, Germany.
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
出版信息
Alzheimers Dement. 2022 Jan;18(1):127-141. doi: 10.1002/alz.12378. Epub 2021 May 29.
INTRODUCTION
We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD).
METHODS
In this quasi-experimental design, 177 periodontally treated patients from the "Greifswald Approach to Individualized Medicine" cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes.
RESULTS
Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95% confidence interval: -0.70 to -0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain.
CONCLUSION
Periodontitis is related to pre-clinical AD in our population.
简介
我们研究了牙周治疗与临床前阿尔茨海默病（AD）之间的关系。
方法
在这项准实验设计中，我们分析了来自“Greifswald 个体化医学方法”队列的 177 名接受牙周治疗的患者和来自基于人群的什未林前瞻性老龄化研究 TREND（SHIP-TREND）的 409 名未接受治疗的患者。在磁共振成像检查时，患者年龄均小于 60 岁，中位观察期为 7.3 年。使用与迟发性 AD 和脑老化相关的脑萎缩影像学标志物作为结果。
结果
经敏感性分析证实，牙周治疗对 AD 相关脑萎缩有积极影响（-0.41；95%置信区间：-0.70 至 -0.12；P =.0051），这相当于从结果分布的第 50 个百分位移到第 37 个百分位。对于脑老化，治疗效果不确定。
结论
在我们的人群中，牙周炎与临床前 AD 有关。
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