应用烧结和非烧结牛骨基质进行临界尺寸缺损的修复 - 小型猪的实验性对照研究。
Critical-size Defect Augmentation Using Sintered and Non-Sintered Bovine Bone Matrix - An Experimental Controlled Study in Minipigs.
机构信息
Resident, Department of Oral, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf Düsseldorf, DE.
Resident, Department of Oral, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Mönchengladbach, DE; Head of Department, Department of Oral, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Mönchengladbach, Germany and Professor, , University Hospital Düsseldorf, Düsseldorf,DE.
出版信息
J Oral Maxillofac Surg. 2021 Sep;79(9):1866-1873. doi: 10.1016/j.joms.2021.03.025. Epub 2021 Apr 6.
PURPOSE
Xenogeneic bone substitute materials are often used for augmentation of larger bone defects. Purification methods for these materials vary, mainly in terms of temperature. The aim of this study was to determine in vivo how sintering affects quantitative and qualitative bone regeneration of 2 bovine augmentation materials.
METHODS
A total of 56 critical size defects were set at the frontal bone of 14 domestic pigs (4 each) and filled randomly with either bovine, sintered hydroxyapatite (BO), bovine, non-sintered hydroxyapatite (BOS), local autologous bone (AB) or left empty. All defects were additionally covered with a collagen membrane. Specimens were harvested after 4 and 8 weeks and were evaluated histologically and histomorphometrically.
RESULTS
Histologically new bone could be seen in every group. Significantly highest new bone formation was found in AB. No significant difference could be detected between BO and BOS.
CONCLUSIONS
According to the results of this study, sintered bone substitute material remains histologically distinguishable but does not affect quantitative and qualitative bone regeneration.
目的
异种骨替代材料常用于增大骨缺损的修复。这些材料的提纯方法各异，主要区别在于温度。本研究旨在体内确定烧结对 2 种牛源性骨修复材料的定量和定性骨再生的影响。
方法
在 14 头国产猪的额骨上共设置了 56 个临界尺寸的缺损（每组 4 个），并随机用牛源性烧结羟基磷灰石（BO）、牛源性未烧结羟基磷灰石（BOS）、局部自体骨（AB）或空白对照进行填充。所有缺损均额外覆盖胶原膜。4 周和 8 周后分别采集标本，进行组织学和组织形态计量学评估。
结果
组织学上，所有组均可见新生骨。AB 组的新生骨形成量最高，差异有统计学意义。BO 组和 BOS 组之间无显著差异。
结论
根据本研究结果，烧结骨替代材料在组织学上仍可区分，但不影响定量和定性骨再生。
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