Department Textile of Engineering, Faculty of Engineering, Bursa Uludag University, Gorukle, Bursa, Turkey.
Department of Chemistry, Faculty of Arts and Science, Bursa Uludag University, Gorukle, Bursa, Turkey.
J Biomater Sci Polym Ed. 2021 Sep;32(13):1718-1735. doi: 10.1080/09205063.2021.1937463. Epub 2021 Jul 14.
Electrospun nanofibers have a natural wound healing effect due to their similarity to the extracellular matrix (ECM). oil, which has therapeutic properties, is used for a wide variety of applications in traditional medicine. The aim of this study was to investigate the release characteristic and wound healing performance of oil (NSO) loaded polyurethane (PU) electrospun nanofibrous mats in wound dressing applications. In addition, the antibacterial activity and cytotoxicity of the electrospun mats were studied. Analyses using a scanning electron microscope (SEM) showed that PU/NSO nanofibrous mat with an average fiber diameter of 416 ± 66 nm were successfully fabricated. NSO was released at a maximum ratio of 30% from the electrospun mat, and the Korsmeyer-Peppas model was identified as best for determining the release mechanism. Significant antibacterial activity was observed against (90.26%) and (95.75%). The developed PU/NSO nanofibrous mat increased the cell viability more than 100% in human umbilical vein endothelial cell line (HUVEC) cell line. The NSO loaded PU nanofibrous mat significantly promoted the wound healing process on a rat wound model, and its wound closure reached approximately 85% compared to the control groups on the 9 day ( < 0.01). The results indicated PU/NSO nanofibrous mat is a suitable candidate for a wound dressing.
静电纺丝纳米纤维因其与细胞外基质 (ECM) 的相似性而具有天然的伤口愈合效果。油具有治疗特性，被广泛应用于传统医学。本研究旨在探讨负载有油（NSO）的聚氨酯（PU）静电纺丝纳米纤维垫在伤口敷料应用中的释放特性和伤口愈合性能。此外，还研究了静电纺丝垫的抗菌活性和细胞毒性。扫描电子显微镜（SEM）分析表明，成功制备了平均纤维直径为 416±66nm 的 PU/NSO 纳米纤维垫。NSO 从静电纺丝垫中以最大 30%的比例释放，Korsmeyer-Peppas 模型被确定为最佳释放机制。对 （90.26%）和 （95.75%）表现出显著的抗菌活性。所开发的 PU/NSO 纳米纤维垫在人脐静脉内皮细胞系（HUVEC）中使细胞活力增加了 100%以上。负载有 NSO 的 PU 纳米纤维垫在大鼠伤口模型上显著促进了伤口愈合过程，与对照组相比，第 9 天的伤口闭合率达到了约 85%（<0.01）。结果表明，PU/NSO 纳米纤维垫是一种适合用作伤口敷料的候选材料。
