Ersanli Caglar, Voidarou Chrysoula Chrysa, Tzora Athina, Fotou Konstantina, Zeugolis Dimitrios I, Skoufos Ioannis
Laboratory of Animal Science, Nutrition and Biotechnology, Department of Agriculture, University of Ioannina, 47100 Arta, Greece.
Laboratory of Animal Health, Food Hygiene and Quality, Department of Agriculture, University of Ioannina, 47100 Arta, Greece.
J Funct Biomater. 2023 Sep 19;14(9):481. doi: 10.3390/jfb14090481.
Herbal extracts have been used in traditional remedies since the earliest myths. They have excellent antimicrobial, anti-inflammatory, and antioxidant activities owing to various bioactive components in their structure. However, due to their inability to reach a target and low biostability, their use with a delivery vehicle has come into prominence. For this purpose, electrospun nanofibrous scaffolds have been widely preferred for the delivery and release of antimicrobial herbal extracts due to the flexibility and operational versatility of the electrospinning technique. Herein, we briefly reviewed the electrospun nanofibrous scaffolds as delivery systems for herbal extracts with a particular focus on the preclinical studies for wound-healing applications that have been published in the last five years. We also discussed the indirect effects of herbal extracts on wound healing by altering the characteristics of electrospun mats.
自最早的神话时代起，草药提取物就已被用于传统疗法。由于其结构中含有各种生物活性成分，它们具有出色的抗菌、抗炎和抗氧化活性。然而，由于它们无法到达靶点且生物稳定性低，因此与递送载体一起使用变得尤为重要。为此，由于静电纺丝技术的灵活性和操作通用性，静电纺丝纳米纤维支架已被广泛用于抗菌草药提取物的递送和释放。在此，我们简要回顾了作为草药提取物递送系统的静电纺丝纳米纤维支架，特别关注过去五年发表的用于伤口愈合应用的临床前研究。我们还讨论了草药提取物通过改变静电纺丝垫的特性对伤口愈合的间接影响。
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