Division of Neurosurgery, Department of Surgery, University of Toronto, 149 College Street, Toronto, Ontario M5T 1P5, Canada; Division of Neurosurgery, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Suite 4W-449, Toronto, Ontario M5T 2S8, Canada.
Division of Neurosurgery, Department of Surgery, University of Toronto, 149 College Street, Toronto, Ontario M5T 1P5, Canada; Division of Neurosurgery, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Suite 4W-449, Toronto, Ontario M5T 2S8, Canada.
Neurosurg Clin N Am. 2021 Jul;32(3):305-313. doi: 10.1016/j.nec.2021.03.002. Epub 2021 May 7.
Spinal cord injury (SCI) triggers a complex cascade of molecular and cellular events that leads to progressive cell loss and tissue damage. In this review, the authors outline the temporal profile of SCI pathogenesis, focusing on key mediators of the secondary injury, and highlight cutting edge insights on the alterations in neural circuits that largely define the chronic injury environment. They bridge these important basic science concepts with clinical implications for informing novel experimental therapies. Furthermore, emerging concepts in the study of SCI pathogenesis that are transforming fundamental research into innovative clinical treatment paradigms are outlined.
脊髓损伤 (SCI) 引发了一系列复杂的分子和细胞事件级联反应，导致进行性细胞死亡和组织损伤。在这篇综述中，作者概述了 SCI 发病机制的时间进程，重点介绍了二次损伤的关键介质，并强调了对神经回路改变的最新见解，这些改变在很大程度上定义了慢性损伤环境。他们将这些重要的基础科学概念与临床意义联系起来，为新的实验治疗提供信息。此外，还概述了 SCI 发病机制研究中正在将基础研究转化为创新临床治疗模式的新兴概念。
