肺中的胆碱能和ACE-2依赖性抗炎系统：COVID-19带来的新情况
The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19.
作者信息
Di Maro Martina, Cataldi Mauro, Santillo Mariarosaria, Chiurazzi Martina, Damiano Simona, De Conno Barbara, Colantuoni Antonio, Guida Bruna
机构信息
Department of Clinical Medicine and Surgery, Physiology Nutrition Unit, University of Naples Federico II, Naples, Italy.
Department of Neuroscience, Reproductive Sciences and Dentistry, Division of Pharmacology, University of Naples Federico II, Naples, Italy.
出版信息
Front Physiol. 2021 May 13;12:653985. doi: 10.3389/fphys.2021.653985. eCollection 2021.
The renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19. We will show how studies performed on this disease are starting to provide evidence that these two anti-inflammatory systems may functionally interact with each other, a mechanism that could have a more general physiological relevance than only COVID-19 infection.
肾素血管紧张素系统和胆碱能抗炎途径最近已被证明可调节新冠肺炎患者的肺部炎症。我们将展示针对这种疾病所开展的研究如何开始提供证据，证明这两种抗炎系统可能在功能上相互作用，这种机制可能具有比仅在新冠肺炎感染中更广泛的生理相关性。
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