Gao Jie, Pan Lin, Bi Ruohong, Shi Yi, Han Yunfeng, Tang Xi, Lai Xianrong
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Evid Based Complement Alternat Med. 2021 May 17;2021:5532159. doi: 10.1155/2021/5532159. eCollection 2021.
Diabetes mellitus (DM) is one of the most serious diseases threatening human health and because of that, it is imperative to look for drugs to tackle it. The Tibetan medicine, a traditional medical system used in China, is currently being the focus of research towards the discovery of new effective drugs against several diseases. Based on the literature survey of Tibetan medicine monographs and drug standards, the Tibetan medicine, and Tibetan prescription used in the traditional Tibetan medical system, here, we summarise the methods indicated for DM treatment. In the Tibetan medical system, 56 types of Tibetan medicine and 25 Tibetan prescriptions were found for the treatment of DM. The most commonly used are Curcuma, Berberidis Cortex, and Carthami Flos. Their names, families, medicinal parts, phytochemical components, and pharmacological activities were described in detail in our research. These Tibetan medicines and prescriptions are valuable gifts from the Tibetan medicine to the world and may be the source of potential drugs for the treatment of DM. With the help of modern phytochemistry, pharmacology, metabonomics, and/or clinical trial methods, further research is needed to prove its medicinal value, identify bioactive components, elucidate potential mechanisms of action, and assess potential side effects or toxicity. This study provides the first available data compilation for the ethnic medical knowledge of Tibetan medicine for the treatment of DM, providing new ideas and sources for drugs against DM.
糖尿病（DM）是威胁人类健康的最严重疾病之一，因此，寻找治疗药物势在必行。藏医药作为中国使用的一种传统医学体系，目前正成为发现针对多种疾病的新型有效药物研究的焦点。基于对藏医药专著和药品标准的文献调研，我们在此总结了传统藏医体系中用于治疗DM的藏药和藏药方。在藏医体系中，发现有56种藏药和25个藏药方用于治疗DM。最常用的是姜黄、黄柏和红花。在我们的研究中详细描述了它们的名称、科属、药用部位、植物化学成分和药理活性。这些藏药和藏药方是藏医药给世界的宝贵礼物，可能是治疗DM潜在药物的来源。借助现代植物化学、药理学、代谢组学和/或临床试验方法，需要进一步研究以证明其药用价值、鉴定生物活性成分、阐明潜在作用机制并评估潜在的副作用或毒性。本研究为藏医药治疗DM的民族医学知识提供了首个可用的数据汇编，为抗DM药物提供了新的思路和来源。
