Daly K, Giebink G S, Le C T, Lindgren B, Batalden P B, Anderson R S, Russ J N
School of Public Health, Division of Epidemiology, University of Minnesota, Minneapolis.
Pediatr Infect Dis J. 1988 Jul;7(7):471-5. doi: 10.1097/00006454-198807000-00004.
Chronic otitis media with effusion (OME) has been observed in 10 to 20% of children following acute, symptomatic otitis media. To determine factors that place children at increased risk of chronic OME, we conducted a 6-week prospective study of 386 children who had 3 or more recent episodes of otitis media and who had middle ear effusion present for at least 2 weeks. Of these children 23% developed chronic OME (i.e. effusion lasting 8 continuous weeks or more), and 26% developed chronic OME complicated by acute, symptomatic otitis media. Predictors for chronic OME were (1) bilateral OME, (2) duration of effusion for greater than 2 weeks at enrollment and (3) day care attendance. Children with these 3 factors had twice the risk of developing chronic OME as children lacking all 3 factors. These risk factors can be used to target children for early, aggressive OME therapy.
在急性症状性中耳炎发作后的儿童中，有10%至20%被观察到患有慢性中耳积液（OME）。为了确定使儿童患慢性OME风险增加的因素，我们对386名近期有3次或更多次中耳炎发作且中耳积液至少持续2周的儿童进行了为期6周的前瞻性研究。在这些儿童中，23%发展为慢性OME（即积液持续8周或更长时间），26%发展为并发急性症状性中耳炎的慢性OME。慢性OME的预测因素为：（1）双侧OME；（2）入组时积液持续时间超过2周；（3）日托出勤情况。具有这3个因素的儿童患慢性OME的风险是缺乏所有这3个因素儿童的两倍。这些风险因素可用于确定早期积极进行OME治疗的儿童。
