Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore, India.
J Food Biochem. 2021 Jul;45(7):e13776. doi: 10.1111/jfbc.13776. Epub 2021 May 30.
The present study was aimed to explore the antiglaucoma activity of capsanthin enriched fraction (CEF) of Capsicum annum L fruits against carbomer-induced experimental glaucoma in Albino Wistar rats. CEF was orally administered to carbomer-induced glaucomatous rats, and pilocarpine 2% eye drops were used as a standard drug. Intraocular pressure (IOP) levels were determined after oral administration of a low, medium, and a high dose of CEF (20, 40, and 80 mg/kg bwt) in glaucomatous rats. In rats with elevated IOP in both eyes, oral administration of CEF resulted in a significant reduction in IOP (p < .05) even at a low dose of 20 mg/Kg body weight. There were no treatment-related changes in histopathology, hematology, and clinical chemistry parameters. Thus, CEF when administered orally in IOP-bearing rats successfully reduced IOP without any adverse effects. PRACTICAL APPLICATIONS: Capsanthin enriched fraction can be used to prevent permanent vision loss due to age-related macular diseases and high intraocular pressure. The intraocular pressure reduction action of capsanthin can be useful in the treatment of glaucoma. The medication available to treat glaucoma are topical drugs, and for the first time, we proved the oral supplementation of capsanthin from a food source can reduce the intraocular pressure in rats.
本研究旨在探索辣椒果实中的辣椒红素富集部分（CEF）对卡波姆诱导的白化 Wistar 大鼠实验性青光眼的抗青光眼活性。CEF 经口给予卡波姆诱导的青光眼大鼠，并用 2%毛果芸香碱滴眼液作为标准药物。在青光眼大鼠中，给予低、中、高剂量 CEF（20、40 和 80mg/kg bwt）后，测定眼内压（IOP）水平。在两只眼眼压升高的大鼠中，即使给予 20mg/kg 体重的低剂量 CEF，也能显著降低 IOP（p<0.05）。组织病理学、血液学和临床化学参数无治疗相关变化。因此，CEF 在眼压升高的大鼠中经口给药可成功降低眼压，而无任何不良反应。实际应用：辣椒红素富集部分可用于预防因年龄相关性黄斑疾病和高眼压引起的永久性视力丧失。辣椒红素的降眼压作用可用于治疗青光眼。现有的治疗青光眼的药物是局部用药物，我们首次证明了从食物来源口服补充辣椒红素可以降低大鼠的眼内压。
