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炎症性肠病中的新型细胞治疗方法:既定概念,有前景的结果。

Novel cell-based therapies in inflammatory bowel diseases: the established concept, promising results.

机构信息

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

出版信息

Hum Cell. 2021 Sep;34(5):1289-1300. doi: 10.1007/s13577-021-00560-w. Epub 2021 May 31.


DOI:10.1007/s13577-021-00560-w
PMID:34057700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8165675/
Abstract

Inflammatory bowel diseases (IBDs) are chronic and relapsing disorders that affect the quality of life in many individuals around the world. Over the past few years, the prevalence of IBDs is substantially rising which might pose a considerable social and economic burden on health systems. Progresses in the management of chronic inflammatory diseases lead to prolonged remission phase and decreased hospitalization rate. However, during treatment, many patients become refractory to conventional therapies. Recently, advanced approaches using somatic cell therapy medicinal products (SCTMPs) including immune and stem cell-based therapies have drawn many researchers' attentions. Promising results from recent trials, alongside with the emerging market indicated that these therapeutic approaches could be an alternative and promising treatment to conventional therapies. In this review, we will discuss recent advances in cell-based therapies, which have been developed for treatment of IBDs. In addition, the global emerging market and the novel products in this field are highlighted.

摘要

炎症性肠病(IBD)是一种慢性复发性疾病,影响着全球许多人的生活质量。在过去的几年中,IBD 的患病率显著上升,这可能给卫生系统带来相当大的社会和经济负担。慢性炎症性疾病管理方面的进展导致缓解期延长和住院率降低。然而,在治疗过程中,许多患者对传统疗法产生了耐药性。最近,使用体细胞治疗药物(SCTMP)的先进方法,包括免疫和基于干细胞的疗法,引起了许多研究人员的关注。最近试验的有希望的结果,以及新兴市场表明,这些治疗方法可能是传统疗法的一种替代和有前途的治疗方法。在这篇综述中,我们将讨论为治疗 IBD 而开发的基于细胞的治疗方法的最新进展。此外,还强调了该领域的全球新兴市场和新产品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffbe/8165675/8f0191cb3d34/13577_2021_560_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffbe/8165675/8b41073d9a79/13577_2021_560_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffbe/8165675/8f0191cb3d34/13577_2021_560_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffbe/8165675/8b41073d9a79/13577_2021_560_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffbe/8165675/8f0191cb3d34/13577_2021_560_Fig2_HTML.jpg

相似文献

[1]
Novel cell-based therapies in inflammatory bowel diseases: the established concept, promising results.

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[2]
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[3]
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[4]
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[5]
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[6]
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[9]
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[10]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Mesenchymal Stromal Cell Therapy Improves Refractory Perianal Fistula in Crohn's Disease: Case Series Clinical Interventional Study.

Cell J. 2022-2

[2]
Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series.

Stem Cell Res Ther. 2021-1-29

[3]
An update to "novel therapeutic approaches for treatment of COVID-19".

J Mol Med (Berl). 2021-2

[4]
Current, New and Future Therapeutic Targets in Inflammatory Bowel Disease: A Systematic Review.

Curr Pharm Des. 2020

[5]
Short and Long Term Clinical and Immunologic Follow up after Bone Marrow Mesenchymal Stromal Cell Therapy in Progressive Multiple Sclerosis-A Phase I Study.

J Clin Med. 2019-12-2

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Inflammopharmacology. 2020-4

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Cells. 2019-10-21

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Gastroenterology. 2019-9-10

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Immunosuppressive Effect of Exosomes from Mesenchymal Stromal Cells in Defined Medium on Experimental Colitis.

Int J Stem Cells. 2019-11-30

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