新加坡临床标本中肺炎克雷伯菌的基因组特征分析。
Genomic Characterization of Klebsiella quasipneumoniae from Clinical Specimens in Singapore.
机构信息
Department of Laboratory Medicine, National University Hospital, Singapore.
National Public Health Laboratory, National Centre for Infectious Diseases, Singapore.
出版信息
Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0041221. doi: 10.1128/AAC.00412-21.
Abstract
A total of 1,281 specimens from 1,024 patients were screened. Phylogenetic analysis classified 44 of these isolates as Klebsiella quasipneumoniae subsp. (44/1,281 [3.4%]) and the remaining three as subsp. The most common specimen source was urine (21/47 [44.7%]) followed by blood (14/47 [29.8%]). isolates were nonclonal. Carbapenemase-encoding genes ( and ) were detected in only two isolates (2/47 [4.3%]). appears to cause a spectrum of infections similar to those of K. pneumoniae, although higher rates of susceptibility to many commonly tested antimicrobials and low prevalence of virulence genes were demonstrated.
摘要
共筛选了 1024 名患者的 1281 份标本。系统发育分析将其中 44 株鉴定为肺炎克雷伯菌亚种（44/1281[3.4%]），其余 3 株鉴定为产酸克雷伯菌亚种。最常见的标本来源是尿液（21/47[44.7%]），其次是血液（14/47[29.8%]）。产酸克雷伯菌分离株是非克隆的。仅在两株菌（2/47[4.3%]）中检测到碳青霉烯酶编码基因（和）。产酸克雷伯菌似乎引起了与肺炎克雷伯菌相似的一系列感染，尽管对许多常用测试的抗菌药物的敏感性更高，且毒力基因的流行率较低。
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