Fatima Hira, Charinpanitkul Tawatchai, Kim Kyo-Seon
Department of Chemical Engineering, Kangwon National University Chuncheon, Kangwon-do 24341, Korea.
Center of Excellence in Particle Technology, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand.
Nanomaterials (Basel). 2021 May 1;11(5):1203. doi: 10.3390/nano11051203.
The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is a promising technique for targeted cancer therapy. The external alternating magnetic field generates heat in the tumor area, which is utilized to kill cancerous cells. Depending on the tumor type and site to be targeted, various types of magnetic nanoparticles, with variable coating materials of different shape and surface charge, have been developed. The tunable physical and chemical properties of magnetic nanoparticles enhance their heating efficiency. Moreover, heating efficiency is directly related with the product values of the applied magnetic field and frequency. Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. This review provides the basics of magnetic hyperthermia, mechanisms of heat losses, thermal doses for hyperthermia therapy, and strategies to improve heating efficiency. The purpose of this review is to build a bridge between the synthesis/coating of magnetic nanoparticles and their practical application in magnetic hyperthermia.
通过外部交变磁场在热疗中激活磁性纳米颗粒是一种很有前景的靶向癌症治疗技术。外部交变磁场在肿瘤区域产生热量，用于杀死癌细胞。根据要靶向的肿瘤类型和部位，已经开发出了各种类型的磁性纳米颗粒，其具有不同形状和表面电荷的可变包覆材料。磁性纳米颗粒可调节的物理和化学性质提高了它们的加热效率。此外，加热效率与所施加磁场和频率的乘积值直接相关。蛋白质冠层的形成是影响磁性纳米颗粒在磁热疗中加热效率的另一个重要参数。本综述提供了磁热疗的基础知识、热损失机制、热疗的热剂量以及提高加热效率的策略。本综述的目的是在磁性纳米颗粒的合成/包覆及其在磁热疗中的实际应用之间架起一座桥梁。
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