Suleiman-Martos Nora, Caballero-Vázquez Alberto, Gómez-Urquiza Jose Luis, Albendín-García Luis, Romero-Béjar Jose Luis, Cañadas-De la Fuente Guillermo A
Faculty of Health Sciencies, University of Granada, Cortadura del Valle S/N, 51001 Ceuta, Spain.
Diagnostic Lung Cancer Unit, Broncopleural Techniques and Interventional Pulmonology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.
J Pers Med. 2021 May 15;11(5):416. doi: 10.3390/jpm11050416.
A respiratory syncytial virus (RSV) is the major cause of respiratory tract infection in children under 5 years. However, RSV infection in the European Region of the World Health Organization has not been systematically reviewed. The aim was to determine the prevalence and factors associated with RSV in children under 5 years of age in European regions. A systematic review and meta-analysis was performed. CINAHL, Medline, LILACS, ProQuest, SciELO, and Scopus databases were consulted for studies published in the last 5 years, following Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The search equation was "respiratory syncytial virus AND (newborn OR infant OR child) AND (prevalence OR risk factors)". Studies reporting the prevalence of RSV were eligible for inclusion in the meta-analysis. A total of 20 articles were included. The meta-analytic prevalence estimation of RSV, with a sample of n = 16,115 children, was 46% (95% CI 34-59%). The main risk factors were age, male gender, winter season, and environmental factors such as cold temperatures, higher relative humidity, high concentrations of benzene, exposure to tobacco, and living in urban areas. Robust age-specific estimates of RSV infection in healthy children should be promoted in order to determine the optimal age for immunization. In addition, it is necessary to analyse in greater depth the potentially predictive factors of RSV infection, to be included in prevention strategies.
呼吸道合胞病毒（RSV）是5岁以下儿童呼吸道感染的主要原因。然而，世界卫生组织欧洲区域的RSV感染情况尚未得到系统综述。目的是确定欧洲各区域5岁以下儿童RSV的患病率及相关因素。进行了一项系统综述和荟萃分析。按照系统综述和荟萃分析的首选报告项目指南，查阅了CINAHL、Medline、LILACS、ProQuest、SciELO和Scopus数据库中过去5年发表的研究。检索式为“呼吸道合胞病毒 AND（新生儿 OR 婴儿 OR 儿童）AND（患病率 OR 危险因素）”。报告RSV患病率的研究符合纳入荟萃分析的条件。共纳入20篇文章。对16115名儿童样本进行的RSV荟萃分析患病率估计为46%（95%CI 34 - 59%）。主要危险因素包括年龄、男性性别、冬季以及寒冷温度、较高相对湿度、高浓度苯、接触烟草和居住在城市地区等环境因素。应推广对健康儿童RSV感染进行可靠的年龄特异性估计，以确定最佳免疫年龄。此外，有必要更深入地分析RSV感染的潜在预测因素，以便纳入预防策略。
