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英国晚期癌症临终关怀患者的社会经济剥夺与症状负担——一项纵向研究的结果

Socio-Economic Deprivation and Symptom Burden in UK Hospice Patients with Advanced Cancer-Findings from a Longitudinal Study.

作者信息

Lloyd-Williams Mari, Shiels Christopher, Dowrick Christopher, Kissane David

机构信息

Academic Palliative and Supportive Care Studies Group, Primary Care and Mental Health, University of Liverpool, Liverpool L69 3BX, UK.

Monash Medical Centre, Monash University, Clayton, VIC 3800, Australia.

出版信息

Cancers (Basel). 2021 May 21;13(11):2537. doi: 10.3390/cancers13112537.

Abstract

Socio-economic deprivation is known to impact on cancer diagnosis, treatment and access to services, but little is known of the impact of socio-economic deprivation on symptom burden in patients with advanced cancer. Patients with advanced cancer attending hospice day services were recruited into a 24 week longitudinal study. An area-based index of social deprivation was collected along with depression and symptom burden at baseline, 8, 16 and 24 weeks. Of the 595 patients included, with an age range of 33-89 years and a mean age of 68 years, 67% were female, and 37% were diagnosed with cancer in the last 12 months. Twenty nine percent lived in one of the most deprived 20% of neighbourhoods. Patients living in the most socio-economically deprived areas were significantly likely to report receiving insufficient information regarding their cancer at diagnosis ( = 0.007), greater pain ( = 0.02), moderate to severe depression ( = 0.04) and higher global symptom burden ( = 0.04). This study is the first to report that patients with advanced cancer attending hospice services, living in the most deprived neighbourhoods experience significantly greater symptom burden, notably depression and pain. We recommend using patient outcome measures in order to provide targeted support and thereby reduce the increased symptom burden that socio-economically disadvantaged patients experience at the end of life.

摘要

社会经济剥夺已知会影响癌症的诊断、治疗以及服务的可及性,但对于社会经济剥夺对晚期癌症患者症状负担的影响却知之甚少。参加临终关怀日间服务的晚期癌症患者被纳入一项为期24周的纵向研究。收集了基于区域的社会剥夺指数以及基线、第8周、第16周和第24周时的抑郁和症状负担数据。在纳入的595名患者中,年龄范围为33至89岁,平均年龄为68岁,67%为女性,37%在过去12个月内被诊断出患有癌症。29%的患者居住在最贫困的20%社区之一。生活在社会经济最贫困地区的患者更有可能报告在诊断时未获得足够的癌症相关信息(P = 0.007)、疼痛更严重(P = 0.02)、有中度至重度抑郁(P = 0.04)以及更高的整体症状负担(P = 0.04)。本研究首次报告,参加临终关怀服务、生活在最贫困社区的晚期癌症患者经历的症状负担明显更重,尤其是抑郁和疼痛。我们建议采用患者结局指标,以便提供有针对性的支持,从而减轻社会经济弱势患者在生命末期所经历的增加的症状负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/8196745/4e12bf94f9d6/cancers-13-02537-g001.jpg

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