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用或不用抗生素,这是个问题:牙科实践中高效有效使用抗生素的最新情况

Antibiotics or No Antibiotics, That Is the Question: An Update on Efficient and Effective Use of Antibiotics in Dental Practice.

作者信息

Buonavoglia Alessio, Leone Patrizia, Solimando Antonio Giovanni, Fasano Rossella, Malerba Eleonora, Prete Marcella, Corrente Marialaura, Prati Carlo, Vacca Angelo, Racanelli Vito

机构信息

Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, 70124 Bari, Italy.

Department of Veterinary Medicine, University of Bari, 70010 Bari, Italy.

出版信息

Antibiotics (Basel). 2021 May 9;10(5):550. doi: 10.3390/antibiotics10050550.

DOI:10.3390/antibiotics10050550
PMID:34065113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8151289/
Abstract

The antimicrobial resistance (AMR) phenomenon is an emerging global problem and is induced by overuse and misuse of antibiotics in medical practice. In total, 10% of antibiotic prescriptions are from dentists, usually to manage oro-dental pains and avoid postsurgical complications. Recent research and clinical evaluations highlight new therapeutical approaches with a reduction in dosages and number of antibiotic prescriptions and recommend focusing on an accurate diagnosis and improvement of oral health before dental treatments and in patients' daily lives. In this article, the most common clinical and operative situations in dental practice, such as endodontics, management of acute alveolar abscesses, extractive oral surgery, parodontology and implantology, are recognized and summarized, suggesting possible guidelines to reduce antibiotic prescription and consumption, maintaining high success rates and low complications rates. Additionally, the categories of patients requiring antibiotic administration for pre-existing conditions are recapitulated. To reduce AMR threat, it is important to establish protocols for treatment with antibiotics, to be used only in specific situations. Recent reviews demonstrate that, in dentistry, it is possible to minimize the use of antibiotics, thoroughly assessing patient's conditions and type of intervention, thus improving their efficacy and reducing the adverse effects and enhancing the modern concept of personalized medicine.

摘要

抗菌药物耐药性(AMR)现象是一个新出现的全球性问题,是由医疗实践中抗生素的过度使用和滥用所导致的。总体而言,10%的抗生素处方来自牙医,通常用于治疗口腔疼痛和避免术后并发症。最近的研究和临床评估强调了新的治疗方法,即减少抗生素处方的剂量和数量,并建议在牙科治疗前以及患者日常生活中注重准确诊断和改善口腔健康。在本文中,我们识别并总结了牙科实践中最常见的临床和手术情况,如牙髓病学、急性牙槽脓肿的处理、口腔拔牙手术、牙周病学和种植牙学,提出了可能的指导方针以减少抗生素的处方和使用量,同时保持高成功率和低并发症发生率。此外,还概述了因既有疾病而需要使用抗生素的患者类别。为了降低AMR的威胁,制定仅在特定情况下使用抗生素的治疗方案很重要。最近的综述表明,在牙科领域,可以通过全面评估患者病情和干预类型来尽量减少抗生素的使用,从而提高其疗效、减少不良反应,并强化个性化医疗的现代理念。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc5/8151289/04d19a3fe4a0/antibiotics-10-00550-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc5/8151289/8d68d002d035/antibiotics-10-00550-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc5/8151289/2dc251c3c266/antibiotics-10-00550-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc5/8151289/04d19a3fe4a0/antibiotics-10-00550-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc5/8151289/8d68d002d035/antibiotics-10-00550-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc5/8151289/2dc251c3c266/antibiotics-10-00550-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc5/8151289/04d19a3fe4a0/antibiotics-10-00550-g003.jpg

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COVID-19 and the potential long-term impact on antimicrobial resistance.COVID-19 与潜在的长期抗菌药物耐药性影响
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Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab VS. zoledronic acid: A systematic review and meta-analysis.
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