Huang J X, He F S, Wu Y G, Zhang S C
Institute of Health, Chinese Academy of Preventive Medicine, Beijing.
Sci Total Environ. 1988 Jun 1;71(3):535-7. doi: 10.1016/0048-9697(88)90230-6.
Renal function was studied in 40 workers chronically exposed to lead at a smelter. The geometric means of lead were 40 (range 24.0 - 63.0) micrograms/dl in blood and 47 (range 19 - 115) micrograms/g creatinine or 71 (range 20 - 250) micrograms/l in urine, respectively. There were no significant differences between the lead-exposed group and a control group in the concentrations of beta 2-microglobulin in serum, urinary total protein and IgG, whereas the level of beta 2-microglobulin in urine was significantly higher in the lead-exposed group (p less than 0.01). No individual lead worker showed abnormally increased level of urinary beta 2-microglobulin. The significance of increased excretion of beta 2-microglobulin on the basis of the group remains to be elucidated.
对40名在冶炼厂长期接触铅的工人的肾功能进行了研究。血液中铅的几何平均值分别为40（范围24.0 - 63.0）微克/分升，尿中为47（范围19 - 115）微克/克肌酐或71（范围20 - 250）微克/升。铅暴露组与对照组在血清β2-微球蛋白浓度、尿总蛋白和IgG方面无显著差异，而铅暴露组尿中β2-微球蛋白水平显著更高（p<0.01）。没有单个铅作业工人尿β2-微球蛋白水平异常升高。基于该组β2-微球蛋白排泄增加的意义仍有待阐明。
