Laboratory for Organ Regeneration, RIKEN Centre for Biosystem Dynamics Research, Hyogo 650-0047, Japan.
ROHTO Pharmaceutical Co., Ltd., Osaka 544-8666, Japan.
Int J Mol Sci. 2021 May 22;22(11):5474. doi: 10.3390/ijms22115474.
In the past decade, a new frontier in scarless wound healing has arisen because of significant advances in the field of wound healing realised by incorporating emerging concepts from mechanobiology and immunology. The complete integumentary organ system (IOS) regeneration and scarless wound healing mechanism, which occurs in specific species, body sites and developmental stages, clearly shows that mechanical stress signals and immune responses play important roles in determining the wound healing mode. Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. This breakthrough in tissue engineering has the potential to accelerate the understanding of wound healing control mechanisms through complex mechanobiological and immunological interactions. In this review, we present an overview of recent studies of biomechanical and immunological wound healing and tissue remodelling mechanisms through comparisons of species- and developmental stage-dependent wound healing mechanisms. We also discuss the possibility of elucidating the control mechanism of wound healing involving mechanobiological and immunological interaction by using next-generation human skin equivalents.
在过去的十年中，由于在创伤愈合领域取得了重大进展，包括从机械生物学和免疫学中引入新兴概念，无疤痕伤口愈合的新领域出现了。完整的表皮器官系统 (IOS) 再生和无疤痕的伤口愈合机制在特定物种、身体部位和发育阶段发生，这清楚地表明机械应力信号和免疫反应在确定伤口愈合模式方面起着重要作用。组织工程技术的进步导致了新型人类皮肤等效物和类器官的产生，这些等效物和类器官再现了具有组织尺度张力平衡的细胞-细胞相互作用，并使我们能够评估皮肤组织形态、功能、药物反应和伤口愈合。组织工程学的这一突破有可能通过复杂的机械生物学和免疫学相互作用来加速对伤口愈合控制机制的理解。在这篇综述中，我们通过比较物种和发育阶段依赖性伤口愈合机制，概述了最近关于生物力学和免疫学伤口愈合和组织重塑机制的研究。我们还讨论了通过使用下一代人类皮肤等效物阐明涉及机械生物学和免疫学相互作用的伤口愈合控制机制的可能性。
