Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 65167198721, Iran.
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran 65167198721, Iran.
Int J Mol Sci. 2021 May 13;22(10):5156. doi: 10.3390/ijms22105156.
Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs).
We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder.
Dysregulated ncRNAs in bipolar patients have been enriched in several neuron-related pathways such as GABAergic and glutamatergic synapses, morphine addiction pathway and redox modulation.
Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients.
双相情感障碍是一种多因素疾病，与多个基因的失调有关。在双相情感障碍的病理生理学中，最近被认可的因素包括非编码 RNA（ncRNA）。
我们检索了 PubMed 和 Google Scholar 数据库，以找到评估双相情感障碍患者 miRNA、lncRNA 和 circRNA 表达谱的研究。
双相情感障碍患者中失调的 ncRNA 富集在几个与神经元相关的途径中，如 GABA 能和谷氨酸能突触、吗啡成瘾途径和氧化还原调节。
这些转录物在双相情感障碍中的异常表达为该疾病发病机制的鉴定和针对患者的靶向治疗方案的设计提供了线索。
