Zawani Mazlan, Fauzi Mh Busra
Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur 56000, Malaysia.
Biomedicines. 2021 May 10;9(5):527. doi: 10.3390/biomedicines9050527.
Diabetic foot ulcers (DFU) are a predominant impediment among diabetic patients, increasing morbidity and wound care costs. There are various strategies including using biomaterials have been explored for the management of DFU. This paper will review the injectable hydrogel application as the most studied polymer-based hydrogel based on published journals and articles. The main key factors that will be discussed in chronic wounds focusing on diabetic ulcers include the socioeconomic burden of chronic wounds, biomaterials implicated by the government for DFU management, commercial hydrogel product, mechanism of injectable hydrogel, the current study of novel injectable hydrogel and the future perspectives of injectable hydrogel for the management of DFU.
糖尿病足溃疡(DFU)是糖尿病患者面临的主要障碍,增加了发病率和伤口护理成本。人们已经探索了多种策略,包括使用生物材料来管理DFU。本文将基于已发表的期刊和文章,综述可注射水凝胶作为研究最多的基于聚合物的水凝胶的应用。在关注糖尿病溃疡的慢性伤口中将要讨论的主要关键因素包括慢性伤口的社会经济负担、政府用于DFU管理的生物材料、商业水凝胶产品、可注射水凝胶的作用机制、新型可注射水凝胶的当前研究以及可注射水凝胶用于DFU管理的未来前景。