Güiza-Argüello Viviana R, Solarte-David Víctor A, Pinzón-Mora Angie V, Ávila-Quiroga Jhair E, Becerra-Bayona Silvia M
Metallurgical Engineering and Materials Science Department, Faculty of Physicochemical Engineering, Universidad Industrial de Santander, Bucaramanga 680002, Colombia.
Program of Biomedical Engineering and Program of Medicine, Faculty of Engineering and Faculty of Health Sciences, Universidad Autónoma de Bucaramanga, Bucaramanga 680003, Colombia.
Polymers (Basel). 2022 Jul 6;14(14):2764. doi: 10.3390/polym14142764.
Diabetic foot ulcers (DFUs) are one of the most prevalent complications associated with diabetes mellitus. DFUs are chronic injuries that often lead to non-traumatic lower extremity amputations, due to persistent infection and other ulcer-related side effects. Moreover, these complications represent a significant economic burden for the healthcare system, as expensive medical interventions are required. In addition to this, the clinical treatments that are currently available have only proven moderately effective, evidencing a great need to develop novel strategies for the improved treatment of DFUs. Hydrogels are three-dimensional systems that can be fabricated from natural and/or synthetic polymers. Due to their unique versatility, tunability, and hydrophilic properties, these materials have been extensively studied for different types of biomedical applications, including drug delivery and tissue engineering applications. Therefore, this review paper addresses the most recent advances in hydrogel wound dressings for effective DFU treatment, providing an overview of current perspectives and challenges in this research field.
糖尿病足溃疡（DFUs）是糖尿病最常见的并发症之一。DFUs是慢性损伤，由于持续感染和其他与溃疡相关的副作用，常导致非创伤性下肢截肢。此外，这些并发症给医疗系统带来了巨大的经济负担，因为需要昂贵的医疗干预。除此之外，目前可用的临床治疗仅被证明有一定效果，这表明迫切需要开发新的策略来改善DFUs的治疗。水凝胶是可以由天然和/或合成聚合物制成的三维体系。由于其独特的多功能性、可调性和亲水特性，这些材料已被广泛研究用于不同类型的生物医学应用，包括药物递送和组织工程应用。因此，本文综述了水凝胶伤口敷料在有效治疗DFUs方面的最新进展，概述了该研究领域的当前观点和挑战。
