Grupo de Catálise e Reatividade Química, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Av. Lourival de Melo Mota, s/n, Maceió/AL 57072-900, Brazil.
Molecules. 2021 May 10;26(9):2796. doi: 10.3390/molecules26092796.
The synthesis of organometallic compounds with potential pharmacological activity has attracted the attention of many research groups, aiming to take advantage of aspects that the presence of the metal-carbon bond can bring to the design of new pharmaceutical drugs. In this context, we have gathered studies reported in the literature in which psychoactive benzodiazepine drugs were used as ligands in the preparation of organometallic and metal complexes and provide details on some of their biological effects. We also highlight that most commonly known benzodiazepine-based drugs display molecular features that allow the preparation of metallacycles via C-H activation. These organometallic compounds merit further attention regarding their potential biological effects, not only in terms of psychoactive drugs but also in the search for drug replacements, for example, for cancer treatments.
具有潜在药理活性的金属有机化合物的合成引起了许多研究小组的关注，旨在利用金属-碳键的存在为新药设计带来的优势。在这方面，我们收集了文献中报道的研究，其中将具有精神活性的苯并二氮䓬类药物用作制备有机金属和金属配合物的配体，并详细介绍了它们的一些生物学效应。我们还强调，最常见的已知苯并二氮䓬类药物具有分子特征，允许通过 C-H 活化制备金属环。这些金属有机化合物值得进一步关注，因为它们具有潜在的生物学效应，不仅在精神活性药物方面，而且在寻找药物替代品方面，例如癌症治疗。
