Cruz Bruna Cristina Dos Santos, Conceição Lisiane Lopes da, Mendes Tiago Antônio de Oliveira, Ferreira Célia Lúcia de Luces Fortes, Gonçalves Reggiani Vilela, Peluzio Maria do Carmo Gouveia
Nutritional Biochemistry Laboratory, Department of Nutrition and Health, Universidade Federal de Viçosa - UFV, Viçosa, Minas Gerais, Brazil.
Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa - UFV, Viçosa, Minas Gerais, Brazil.
Food Res Int. 2020 Nov;137:109721. doi: 10.1016/j.foodres.2020.109721. Epub 2020 Sep 25.
Individuals with inflammatory bowel disease are at high risk of developing colitis-associated cancer; thus, strategies to inhibit disease progression should be investigated. The study aimed to explore the role of the synbiotic (probiotic VSL#3® and yacon-based concentrate) in a colitis-associated carcinogenesis model. IL-10 mice were induced to carcinogenesis with 1,2-dimethylhydrazine and divided into two experimental groups: control and synbiotic. Manifestations of colitis, colon histology, expression of antioxidant enzymes, production of organic acids and intestinal microbiota were evaluated. The use of the synbiotic showed benefits, such as the preservation of intestinal architecture, increased expression of antioxidant enzymes and the concentration of organic acids, especially butyrate. It was also observed different microbial community profiles between the groups during the study. Together, these factors contributed to mitigate the manifestations of colitis and improve intestinal integrity, suggesting the potential benefit of the synbiotic in intestinal diseases.
炎症性肠病患者患结肠炎相关癌症的风险很高；因此，应研究抑制疾病进展的策略。该研究旨在探讨合生元（益生菌VSL#3®和基于雪莲果的浓缩物）在结肠炎相关致癌模型中的作用。用1,2 - 二甲基肼诱导IL - 10小鼠发生癌变，并分为两个实验组：对照组和合生元组。评估了结肠炎的表现、结肠组织学、抗氧化酶的表达、有机酸的产生和肠道微生物群。使用合生元显示出益处，如保留肠道结构、增加抗氧化酶的表达和有机酸的浓度，尤其是丁酸盐。在研究过程中还观察到两组之间不同的微生物群落特征。这些因素共同有助于减轻结肠炎的表现并改善肠道完整性，表明合生元在肠道疾病中具有潜在益处。
