Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, Spain.
Center of Biomedical Research, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Armilla, 18016 Granada, Spain.
Nutrients. 2021 May 14;13(5):1673. doi: 10.3390/nu13051673.
During early life, dynamic gut colonization and brain development co-occur with potential cross-talk mechanisms affecting behaviour.
We used 16S rRNA gene sequencing to examine the associations between gut microbiota and neurodevelopmental outcomes assessed by the Bayley Scales of Infant Development III in 71 full-term healthy infants at 18 months of age. We hypothesized that children would differ in gut microbial diversity, enterotypes obtained by Dirichlet multinomial mixture analysis and specific taxa based on their behavioural characteristics.
In children dichotomized by behavioural trait performance in above- and below-median groups, weighted Unifrac b-diversity exhibited significant differences in fine motor (FM) activity. Dirichlet multinomial mixture modelling identified two enterotypes strongly associated with FM outcomes. When controlling for maternal pre-gestational BMI and breastfeeding for up to 3 months, the examination of signature taxa in FM groups showed that and were highly abundant in the below-median FM group, while , , , , , , , , an unassigned genus within and, interestingly, probiotic and were more abundant in the above-median FM group.
Our results suggest an association between enterotypes and specific genera with FM activity and may represent an opportunity for probiotic interventions relevant to treatment for motor disorders.
在生命早期，动态的肠道定植和大脑发育同时发生，并存在潜在的相互作用机制，影响行为。
我们使用 16S rRNA 基因测序来研究肠道微生物群与神经发育结果之间的关联，这些结果通过贝利婴幼儿发展量表第三版（Bayley Scales of Infant Development III）在 71 名足月健康婴儿 18 个月时进行评估。我们假设，儿童的肠道微生物多样性、通过 Dirichlet 多项混合分析获得的肠型以及基于行为特征的特定分类群会存在差异。
在根据行为特征表现将儿童分为高于和低于中位数组后，加权 UniFrac b-多样性在精细运动（FM）活动方面存在显著差异。Dirichlet 多项混合模型确定了与 FM 结果密切相关的两种肠型。当控制母亲孕前 BMI 和母乳喂养至 3 个月时，对 FM 组中特征分类群的检查表明，在低于中位数的 FM 组中，和 高度丰富，而 、 、 、 、 、 、一个未被分配的属内 和 ，有趣的是，益生菌 和 更丰富于高于中位数的 FM 组。
我们的结果表明肠型与 FM 活动的特定分类群之间存在关联，这可能为与运动障碍治疗相关的益生菌干预提供机会。
