Warren J B, Dalton N, Turner C, Clark T J, Toseland P A
Clin Sci (Lond). 1984 Jan;66(1):87-90. doi: 10.1042/cs0660087.
By studying six normal subjects during graduated treadmill exercise, we have confirmed that there is very little rise in venous plasma adrenaline levels during mild or moderate exercise. During a second study, adrenaline was infused intravenously in six resting subjects at a rate of 0.025 micrograms min-1 kg-1. This elevated the basal plasma adrenaline level from 0.28 +/- 0.04 nmol/l to 0.92 +/- 0.16, 1.16 +/- 0.20 and 1.28 +/- 0.19 nmol/l at 3, 5 and 7 min after the start of the infusion. The same adrenaline infusion was repeated in the same subjects 7 min after they started moderate exercise at a constant rate on a static exercise bicycle. Just before the start of the infusion, 7 min after the onset of exercise, plasma adrenaline had risen to 0.36 +/- 0.07 nmol/l. This rose to 1.86 +/- 0.30, 1.98 +/- 0.26 and 2.19 +/- 0.29 nmol/l at 3, 5 and 7 min after the start of this second infusion. Five minutes after the end of the infusion, while the subjects were still exercising, the mean level was 0.56 +/- 0.04 nmol/l. The venous plasma level of adrenaline is the result of a balance between the secretion of adrenaline by the adrenal medulla and the clearance of adrenaline from plasma. Our results suggest that the lack of any significant rise in plasma adrenaline during moderate exercise does not result from an accelerated clearance of adrenaline by exercising tissue. The clearance rate of adrenaline from plasma is reduced during exercise. There is no significant increase in secretion by the adrenal medulla in response to the stimulus of mild or moderate exercise.
通过对6名正常受试者进行递增式跑步机运动研究，我们证实，在轻度或中度运动期间，静脉血浆肾上腺素水平几乎没有升高。在第二项研究中，对6名静息受试者以0.025微克·分钟⁻¹·千克⁻¹的速率静脉输注肾上腺素。这使基础血浆肾上腺素水平从0.28±0.04纳摩尔/升分别在输注开始后3、5和7分钟时升高至0.92±0.16、1.16±0.20和1.28±0.19纳摩尔/升。在同一受试者以恒定速率在静态健身自行车上开始中度运动7分钟后，重复相同的肾上腺素输注。就在输注开始前，运动开始7分钟后，血浆肾上腺素已升至0.36±0.07纳摩尔/升。在第二次输注开始后3、5和7分钟时，这一水平分别升至1.86±0.30、1.98±0.26和2.19±0.29纳摩尔/升。输注结束5分钟后，受试者仍在运动时，平均水平为0.56±0.04纳摩尔/升。静脉血浆肾上腺素水平是肾上腺髓质分泌肾上腺素与血浆中肾上腺素清除之间平衡的结果。我们的结果表明，中度运动期间血浆肾上腺素没有显著升高并非由于运动组织加速清除肾上腺素所致。运动期间血浆中肾上腺素的清除率降低。肾上腺髓质对轻度或中度运动刺激的分泌没有显著增加。
