School of Forestry and Resource Conservation, National Taiwan University, Taipei 106, Taiwan.
Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei 104, Taiwan.
Molecules. 2021 May 19;26(10):3037. doi: 10.3390/molecules26103037.
plants (Lauraceae) are a woody species native to South and Southeast Asia forests, and are widely used as food flavors and traditional medicines. This study aims to evaluate the chemical constituents of ct. linalool leaf oil, and its antidepressant and motor coordination activities and the other behavioral evaluations in a rodent animal model. The major component of leaf oil is linalool, confirmed by GC-MS analysis. Leaf oil would not induce the extra body weight gain compared to the control mice at the examined doses after 6 weeks of oral administration. The present results provide the first evidence for motor coordination and antidepressant effects present in leaf oil. According to hypnotic, locomotor behavioral, and motor coordination evaluations, leaf oil would not cause side effects, including weight gain, drowsiness and a diminishment in the motor functions, at the examined doses. In summary, these results revealed ct. linalool leaf essential oil is of high potential as a therapeutic supplement for minor/medium depressive syndromes.
植物（樟科）是原产于南亚和东南亚森林的木本物种，被广泛用作食品香料和传统药物。本研究旨在评估 ct. 芳樟醇叶油的化学成分，及其在啮齿动物模型中的抗抑郁和运动协调活性以及其他行为评估。通过 GC-MS 分析，确定叶油的主要成分是芳樟醇。与对照组相比，在 6 周的口服给药后，叶油在检查剂量下不会导致额外的体重增加。目前的结果为叶油中存在的运动协调和抗抑郁作用提供了第一个证据。根据催眠、运动行为和运动协调评估，在检查剂量下，叶油不会引起副作用，包括体重增加、嗜睡和运动功能减退。总之，这些结果表明 ct. 芳樟醇叶精油具有作为治疗轻度/中度抑郁综合征的补充剂的高潜力。
